| Author | Araujo-Jorge, Tania Cremonini de | |
| Author | Ferreira, Roberto R. | |
| Access date | 2022-03-21T17:47:09Z | |
| Available date | 2022-03-21T17:47:09Z | |
| Document date | 2022 | |
| Citation | ARAUJO-JORGE, Tania Cremonini de; FERREIRA, Roberto R. Translational research in Chagas disease: perspectives in nutritional therapy emerging from selenium supplementation studies as a complementary treatment. Memórias do Instituto Oswaldo Cruz. v. 117, e220001, p. 1-4, 2022. | |
| ISSN | 0074-0206 | |
| URI | https://www.arca.fiocruz.br/handle/icict/51778 | |
| Description | Produção científica do Laboratório de Inovações em Terapias, Ensino e Bioprodutos. | pt_BR |
| Language | eng | en_US |
| Publisher | Fiocruz/IOC | |
| Rights | open access | |
| Subject in Portuguese | Trypanosoma cruzi | pt_BR |
| Subject in Portuguese | Vestígios | pt_BR |
| Subject in Portuguese | Doenças tropicais negligenciadas | pt_BR |
| Subject in Portuguese | Miocardiopatia | pt_BR |
| Subject in Portuguese | Selênio | pt_BR |
| Title | Translational research in Chagas disease: perspectives in nutritional therapy emerging from selenium supplementation studies as a complementary treatment | en_US |
| Type | Article | |
| DOI | 10.1590/0074-02760220001 | |
| Abstract | Translational research (TR) is an interdisciplinary branch of the biomedical field that seeks to connect its three supporting pillars: basic research on the bench, the hospital beds and other health system services, and the delivery of products for the wellbeing and health of the community. Here, we review the five transition stages of the TR spectrum, registering the lessons learned during > 20 years leading to the first clinical trial designed and performed in Brazil for testing a complementary treatment for Chagas disease (CD): the selenium trial (STCC). Lessons learned were: (1) to consider all the TR spectrum since the beginning of the project; (2) to start simultaneously animal studies and translation to humans; (3) to ensure a harmonious interaction between clinical and basic research teams; (4) to include MSc and PhD students only in pre-clinical and basic studies (TR0) or vertical clinical studies using retrospective samples and data (TR1); (5) to identify potential suppliers in the national commercial market for a future final treatment since the pre-clinical stage; (6) to keep an international network of experts as permanent advisers on the project. In the whole process, some perspectives were created: a complementary clinical trial for the opened questions and the construction of a Brazilian clinical CD platform. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovação em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovação em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil. | |
| Subject | Trace elements | pt_BR |
| Subject | Neglected tropical diseases | en_US |
| Subject | Myocardiopathy | en_US |
| Subject | Trypanosoma cruzi | en_US |
| Subject | Selenium | en_US |
| e-ISSN | 1678-8060 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
