Author | Soeiro, Maria de Nazaré Correia | |
Access date | 2022-03-21T18:33:02Z | |
Available date | 2022-03-21T18:33:02Z | |
Document date | 2022 | |
Citation | SOEIRO, Maria Nazaré Correia. Perspectives for a new drug candidate for Chagas disease therapy. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 117, e220004, p. 1-7, 2002. | pt_BR |
ISSN | 0074-0206 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/51788 | |
Language | eng | pt_BR |
Publisher | Fiocruz/IOC | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Trypanosoma cruzi | pt_BR |
Subject in Portuguese | Quimioterapia experimental | pt_BR |
Subject in Portuguese | Doença de Chagas | pt_BR |
Subject in Portuguese | Candidatos a drogas | pt_BR |
Subject in Portuguese | Prova de conceito | pt_BR |
Subject in Portuguese | Inibidores da Fosfodiesterase | pt_BR |
Title | Perspectives for a new drug candidate for Chagas disease therapy | pt_BR |
Type | Article | pt_BR |
DOI | 10.1590/0074-02760220004 | |
Abstract | Chagas disease (CD), a neglected tropical illness caused by the protozoan Trypanosoma cruzi, affects more than 6 million people mostly in poor areas of Latin America. CD has two phases: an acute, short phase mainly oligosymptomatic followed to the chronic phase, a long-lasting stage that may trigger cardiac and/or digestive disorders and death. Only two old drugs are available and both present low efficacy in the chronic stage, display side effects and are inactive against parasite strains naturally resistant to these nitroderivatives. These shortcomings justify the search for novel therapeutic options considering the target product profile for CD that will be presently reviewed besides briefly revisiting the data on phosphodiesterase inhibitors upon T. cruzi. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Trypanosoma cruzi | pt_BR |
Subject | Experimental chemotherapy | pt_BR |
Subject | Chagas disease | pt_BR |
Subject | Drug candidates | pt_BR |
Subject | Proof of concept | pt_BR |
Subject | Phosphodiesterase inhibitors | pt_BR |
e-ISSN | 1678-8060 | |