| Author | Biembengut, Ísis Venturi | |
| Author | Silva, Isabelle Leticia Zaboroski | |
| Author | Souza, Tatiana de Arruda Campos Brasil de | |
| Author | Shigunov, Patrícia | |
| Access date | 2022-03-24T17:06:13Z | |
| Available date | 2022-03-24T17:06:13Z | |
| Document date | 2021 | |
| Citation | BIEMBENGUT, Ísis Venturi et al. Cytoplasmic FMR1 interacting protein (CYFIP) family members and their function in neural development and disorders. Molecular Biology Reports, n. 48, p. 6131–6143, 2021. | pt_BR |
| ISSN | 1573-4978 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/51859 | |
| Language | por | pt_BR |
| Publisher | Springer | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | CYFIP | pt_BR |
| Subject in Portuguese | Proteínas citoplasmáticas de interação | pt_BR |
| Title | Cytoplasmic FMR1 interacting protein (CYFIP) family members and their function in neural development and disorders | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1007/s11033-021-06585-6 | |
| Abstract | In humans, the cytoplasmic FMR1 interacting protein (CYFIP) family is composed of CYFIP1 and CYFIP2. Despite their high similarity and shared interaction with many partners, CYFIP1 and CYFIP2 act at diferent points in cellular processes. CYFIP1 and CYFIP2 have diferent expression levels in human tissues, and knockout animals die at diferent time points of development. CYFIP1, similar to CYFIP2, acts in the WAVE regulatory complex (WRC) and plays a role in actin dynamics through the activation of the Arp2/3 complex and in a posttranscriptional regulatory complex with the fragile X mental retardation protein (FMRP). Previous reports have shown that CYFIP1 and CYFIP2 may play roles in posttranscriptional regulation in diferent ways. While CYFIP1 is involved in translation initiation via the 5′UTR, CYFIP2 may regulate mRNA expression via the 3′UTR. In addition, this CYFIP protein family is involved in neural development and maturation as well as in diferent neural disorders, such as intellectual disabilities, autistic spectrum disorders, and Alzheimer’s disease. In this review, we map diverse studies regarding the functions, regulation, and implications of CYFIP proteins in a series of molecular pathways. We also highlight mutations and their structural efects both in functional studies and in neural diseases. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil. | pt_BR |
| Subject | Fragile X Mental Retardation Protein | pt_BR |
| Subject | Wave regulatory complex | pt_BR |
| Subject | Nerve Growth Factors | pt_BR |
| Subject | Nerve Degeneration | pt_BR |
| Subject in Spanish | Proteína del Retraso Mental del Síndrome del Cromosoma X Frágil | pt_BR |
| Subject in Spanish | Factores de Crecimiento Nervioso | pt_BR |
| Subject in Spanish | Degeneración Nerviosa | pt_BR |
| Subject in French | Protéine du syndrome X fragile | pt_BR |
| Subject in French | Facteurs de croissance nerveuse | pt_BR |
| Subject in French | Dégénérescence nerveuse | pt_BR |
| DeCS | Proteína do X Frágil de Retardo Mental | pt_BR |
| DeCS | Fatores de Crescimento Neural | pt_BR |
| DeCS | Degeneração Neural | pt_BR |
