| Author | Goes, Alfredo Miranda de | |
| Author | Rezende, Simone Aparecida | |
| Author | Gazzinelli, Giovanni | |
| Author | Doughty, Barbara L. | |
| Access date | 2022-04-06T12:08:17Z | |
| Available date | 2022-04-06T12:08:17Z | |
| Document date | 1994 | |
| Citation | GOES, Alfredo Miranda de et al. Granulomatous hypersensitivity to Schistosoma mansoni: a role for protaglandin-induced inhibition of in vitro granuloma formation. Parasite Immunol., v. 16, n. 1, p. 11-18, 1994. doi.org/10.1111/j.1365-3024.1994.tb00299.x | pt_BR |
| ISSN | 0141-9838 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/52051 | |
| Language | eng | pt_BR |
| Publisher | Wiley | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Immune complexes | pt_BR |
| Subject in Portuguese | Mononuclear cells | pt_BR |
| Title | Granulomatous hypersensitivity to Schistosoma mansoni egg antigens in human schistosomiasis. IV. A role for prostaglandin-induced inhibition of in vitro granuloma formation. | pt_BR |
| Type | Article | |
| DOI | 10.1111/j.1365-3024.1994.tb00299.x | |
| Abstract | The prostaglandins (PG) are known to regulate immune cell function (s) and participate in the progression of both acute and chronic inflammatory reactions. Using an in vitro model of Schistosoma mansoni egg-induced hypersensitivity granulomas, we have delineated the role of immune complexes (IC) in the induction andrelease of PG and their inhibitory effects on granuloma development. The hypersensitivity- type granuloma reaction to soluble egg antigen (SEA) was examined using a model of in vitro granuloma ,formation. Our results show that granuloma formation was dramatically suppressed by the addition to the granuloma cultures of IC, PGE,, PGE2, while PGF, alpha had no significant effect. The inhibition of the PG function was achieved by the introduction of anti-PG antibodies that blocked suppression of granuloma, formation. It appears in this model system that IC may inhibit the activity of granuloma formation by stimulating the monocyte-macrophage lineage to release inhibitory mediators. Our results suggest that the prostaglandins E series may be important in the generation and maintenance of suppression of the granulomatous inflammatory response to S. mansoni egg antigens. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Department of Veterinary Pathobiology. College of Veterinary Medicine. Texas A & M University. College Station. Texas, TX, USA. | pt_BR |
