| Author | Celes, Fabiana S. | |
| Author | Barud, Hernane S. | |
| Author | Viana, Sayonara M. | |
| Author | Borba, Pedro B. | |
| Author | Machado, Paulo R. L. | |
| Author | Carvalho, Edgar M. | |
| Author | Oliveira, Camila I. de | |
| Access date | 2022-04-06T13:40:17Z | |
| Available date | 2022-04-06T13:40:17Z | |
| Document date | 2022 | |
| Citation | CELES, Fabiana S. et al. A pilot and open trial to evaluate topical bacterial cellulose bio-curatives in the treatment of cutaneous leishmaniasis caused by L. braziliensis. Acta Tropica, v. 225, p. 1-5, 2022. | pt_BR |
| ISSN | 0001-706X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/52056 | |
| Sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Coordenação de Aperfeiçoamento
de Pessoal de Nível Superior (CAPES). Fundação de Amparo à Pesquisa de São Paulo (FAPESP). TA Instruments Brasil | pt_BR |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Leishmaniose | pt_BR |
| Subject in Portuguese | Antimônio | pt_BR |
| Subject in Portuguese | Ensaio clínico | pt_BR |
| Subject in Portuguese | Tratamento farmacológico | pt_BR |
| Title | A pilot and open trial to evaluate topical bacterial cellulose bio-curatives in the treatment of cutaneous leishmaniasis caused by L. braziliensis | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1016/j.actatropica.2021.106192 | |
| Abstract | The treatment of cutaneous leishmaniasis (CL) in Brazil using pentavalent antimony (Sbv) is associated with a high failure rate and long time to heal. Moreover, standard Sbv treatment cures only 50–60% of the cases. In this pilot clinical trial, we evaluated the topical use of bacterial cellulose (BC) bio-curatives + Sbv in the treatment of CL caused by L. braziliensis, in Bahia, Brazil. A total of 20 patients were randomized in two groups assigned to receive either parenteral Sbv alone or parenteral Sbv plus topically applied BC bio-curatives. CL patients treated with Sbv + topical BC bio-curatives had a significantly higher cure rate at 60 days post initiation of treatment compared to CL patients treated with Sbv alone (P=0.01). At day 90 post initiation of treatment, cure rate was similar in the two groups as was overall healing time. Adverse effects or local reactions to topical BC application were not observed. This pilot trial shows that the potential use of a combined therapy consisting of topical BC bio-curatives and parenteral Sbv in favoring healing of CL lesions caused by L. braziliensis, at an early time point. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade de Araraquara - Uniara. Araraquara, SP, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Hospital Universitário Professor Edgard Santos - Hupes. Serviço de Imunologia. Salvador, BA, Brasil / Instituto de Investigação em Doenças Tropicais - INCT. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Hospital Universitário Professor Edgard Santos - Hupes. Serviço de Imunologia. Salvador, BA, Brasil / Instituto de Investigação em Doenças Tropicais - INCT. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Investigação em Doenças Tropicais - INCT. Salvador, BA, Brasil. | pt_BR |
| Subject | Leishmaniasis | pt_BR |
| Subject | Antimony | pt_BR |
| Subject | Clinical trial | pt_BR |
| Subject | Drug therapy | pt_BR |
| Subject in Spanish | Leishmaniasis | pt_BR |
| Subject in Spanish | Antimonio | pt_BR |
| Subject in Spanish | Ensayo clínico | pt_BR |
| Subject in Spanish | Quimioterapia | pt_BR |
| Subject in French | Leishmaniose | pt_BR |
| Subject in French | Antimoine | pt_BR |
| Subject in French | Essai clinique | pt_BR |
| Subject in French | Traitement médicamenteux | pt_BR |
