Author | Almeida, Gregório Guilherme | |
Author | Costa, Pedro Augusto Carvalho | |
Author | Araujo, Maísa da Silva | |
Author | Gomes, Gabriela Ribeiro | |
Author | Carvalho, Alex Fiorini | |
Author | Figueiredo, Maria Marta | |
Author | Pereira, Dhelio Batista | |
Author | Tada, Mauro Shugiro | |
Author | Medeiros, Jansen Fernandes | |
Author | Soares, Irene da Silva | |
Author | Carvalho, Luzia Helena | |
Author | Kano, Flora Satiko | |
Author | Castro, Marcia Caldas de | |
Author | Vinetz, Joseph Michael | |
Author | Golenbock, Douglas Taylor | |
Author | Antonelli, Lis Ribeiro do Valle | |
Author | Gazzinelli, Ricardo Tostes | |
Access date | 2022-04-11T13:16:42Z | |
Available date | 2022-04-11T13:16:42Z | |
Document date | 2021 | |
Citation | ALMEIDA, Gregório Guilherme et al. Asymptomatic Plasmodium vivax malaria in the Brazilian Amazon: Submicroscopic parasitemic blood infects Nyssorhynchus darlingi. PLoS Negl Trop Dis., v. 15, n. 10, e0009077, 2021. doi: 10.1371/journal.pntd.0009077. | pt_BR |
ISSN | 1935-2735 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/52148 | |
Language | eng | pt_BR |
Publisher | Public Library of Science | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | malaria | pt_BR |
Subject in Portuguese | P. vivax | pt_BR |
Title | Asymptomatic Plasmodium vivax malaria in the Brazilian Amazon: Submicroscopic parasitemic blood infects Nyssorhynchus darlingi | pt_BR |
Type | Article | pt_BR |
DOI | 10.1371/journal.pntd.0009077 | |
Abstract | Individuals with asymptomatic infection due to Plasmodium vivax are posited to be important reservoirs of malaria transmission in endemic regions. Here we studied a cohort of P. vivax malaria patients in a suburban area in the Brazilian Amazon. Overall 1,120 individuals were screened for P. vivax infection and 108 (9.6%) had parasitemia detected by qPCR but not by microscopy. Asymptomatic individuals had higher levels of antibodies against P. vivax and similar hematological and biochemical parameters compared to uninfected controls. Blood from asymptomatic individuals with very low parasitemia transmitted P. vivax to the main local vector, Nyssorhynchus darlingi. Lower mosquito infectivity rates were observed when blood from asymptomatic individuals was used in the membrane feeding assay. While blood from symptomatic patients infected 43.4% (199/458) of the mosquitoes, blood from asymptomatic infected 2.5% (43/1,719). However, several asymptomatic individuals maintained parasitemia for several weeks indicating their potential role as an infectious reservoir. These results suggest that asymptomatic individuals are an important source of malaria parasites and Science and Technology for Vaccines granted by Conselho Nacional de may contribute to the transmission of P. vivax in low-endemicity areas of malaria | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Biologia e Imunologia de Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Imunopatologia. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Biologia e Imunologia de Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Fiocruz Rondônia Laboratório de Entomologia. Porto Velho, RO, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Biologia e Imunologia de Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil. Fundação Oswaldo Cruz. Instituto René Rachou. CT vacinas. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil. Fundação Oswaldo Cruz. Instituto René Rachou. CT vacinas. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Centro de Pesquisa em Medicina Tropical. Ambulatório de Malária. Porto Velho, RO, Brazil. | pt_BR |
Affilliation | Centro de Pesquisa em Medicina Tropical. Ambulatório de Malária. Porto Velho, RO, Brazil. | pt_BR |
Affilliation | Fiocruz Rondônia Laboratório de Entomologia. Porto Velho, RO, Brazil. | pt_BR |
Affilliation | Universidade Federal de São Paulo. Departamento de Microbiologia, Imunologia e Parasitologia. São Paulo, SP, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Biologia Molecular e Imunologia da Malária. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Biologia Molecular e Imunologia da Malária. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Department of Global Health and Population. Harvard T.H. Chan School of Public Health. Boston, MA, United States of America. | pt_BR |
Affilliation | Section of Infectious Diseases. Department of Internal Medicine. Yale School of Medicine. New Haven, CT, United States of America. | pt_BR |
Affilliation | Department of Medicine. University of Massachusetts Medical School. Worcester, MA, United States of America. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Biologia e Imunologia de Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Imunopatologia. Belo Horizonte, MG, Brazil/Department of Medicine. University of Massachusetts Medical School. Worcester, MA, United States of America. | pt_BR |