| Author | Boniatti, Janine | |
| Author | Tappin, Marcelo R. R. | |
| Author | Teixeira, Rafaela G. da S. | |
| Author | Gandos, Tamires A. V. | |
| Author | Rios, Luis P. S. | |
| Author | Ferreira, Izabelle A. M. | |
| Author | Oliveira, Karina C. | |
| Author | Calil-Elias, Sabrina | |
| Author | Santana, Aila K. M. | |
| Author | Fonseca, Laís B. da | |
| Author | Shimizu, Flavio M. | |
| Author | Carr, Olívia | |
| Author | Oliveira Jr, Osvaldo N. | |
| Author | Dantas, Fabio M. L. | |
| Author | Amendoeira, Fabio C. | |
| Author | Viçosa, Alessandra L. | |
| Access date | 2022-05-03T19:30:36Z | |
| Available date | 2022-05-03T19:30:36Z | |
| Document date | 2022 | |
| Citation | BONIATTI, Janine et al. In Vivo and In Vitro Taste Assessment of Artesunate-Mefloquine, Praziquantel, and Benznidazole Drugs for Neglected Tropical Diseases and Pediatric Patients. AAPS PharmSciTech, v. 23, n. 22, p. 1-10, Dec. 2022. | pt_BR |
| ISSN | 1530-9932 | |
| URI | https://www.arca.fiocruz.br/handle/icict/52521 | |
| Description | Inclui errata. | |
| Sponsorship | The authors are grateful for the fnancial support by PAPES VII, PROEP/FAR/CNPq/Fiocruz, CNPQ, and FAPESP (2018/22214-6). Also, we would like to thank Luciano Simoes Pereirafor all support with the image treatment and the recirculation system construction. The authors also thank Angelo L. Gobbi and Maria H. O.
Piazzetta for their technical assistance in the microfabrication laboratory (LMF/LNNano/CNPEM). | pt_BR |
| Language | eng | pt_BR |
| Publisher | American Association of Pharmaceutical Scientists | pt_BR |
| Rights | restricted access | pt_BR |
| Title | In vivo and in vitro taste assessment of artesunate-mefloquine, praziquantel, and benznidazole drugs for neglected tropical diseases and pediatric patients | pt_BR |
| Type | Article | |
| DOI | 10.1208/s12249-021-02162-z | |
| Abstract | The assessment of drug taste is crucial for pediatric treatments so that formulations can be developed to enhance their efectiveness. In this study, in vivo and in vitro methods were applied to evaluate the taste of tablets of three drugs administered to children without taste-masking excipients to treat tropical diseases, namely artesunate-mefoquine (ASMQ), praziquantel (PZQ), and benznidazole (BNZ). In the frst method, a model of rat palatability was adapted with recirculation to ensure sample dispersion, and the data were analyzed using ANOVA (single factor, 95%). The taste assessment results (in vivo) indicated an aversion to the three medicines, denoted by the animals retracting themselves to the bottom of the box after the frst contact with the drugs. For the placebo samples, the animals behaved normally, indicating that taste perception was acceptable. The second method was based on the in vitro analysis of capacitance data from a homemade impedimetric electronic tongue. Consistent with the in vivo taste assessment results, the data points obtained with PZQ, ASMQ, and BNZ were far away from those of their placebos in a map built with the multidimensional projection technique referred to as Interactive Document Mapping (IDMAP). A combined analysis of the results with the two methods allowed us to confrm the bitterness of the three drugs, also pointing to electronic tongues as a promising tool to replace in vivo palatability tests. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos (Farmanguinhos). Rio de Janeiro, RJ, Brasil / Instituto Nacional de Tecnologia. Departamento de Material. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos (Farmanguinhos). Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto de Farmácia. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos (Farmanguinhos). Rio de Janeiro, RJ, Brasil / Universidade Federal Fluminense. Faculdade de Farmácia. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Faculdade de Farmácia. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Faculdade de Farmácia. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Faculdade de Farmácia. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Faculdade de Farmácia. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Laboratório Farmacêutico de Pernambuco. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos (Farmanguinhos). Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Universidade Estadual de Campinas. Instituto de Física "Gleb Wataghin". Departamento de Física Aplicada. Campinas, SP, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Instituto de Física São Carlos. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Instituto de Física São Carlos. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Instituto Nacional de Tecnologia. Departamento de Material. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos (Farmanguinhos). Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos (Farmanguinhos). Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Artesunate-mefloquine | pt_BR |
| Subject | Benznidazole | pt_BR |
| Subject | Electronic tongue | pt_BR |
| Subject | Modified taste aversion model | pt_BR |
| Subject | Off-label use | pt_BR |
| Subject | Pediatric treatment | pt_BR |
| Subject | Praziquantel | |
| Embargo date | 2030-12-31 | |
