| Author | Duarte, Fernanda Gross | |
| Author | Barberino, Maria Goreth | |
| Author | Moreira, Sandra da Silva | |
| Author | Reis, Joice Neves | |
| Author | Spinardi, Julia Regazzini | |
| Author | Almeida, Rodrigo Sini de | |
| Author | Allen, Kristen E | |
| Author | Parrish, Ronika Alexander | |
| Author | Brim, Rosa | |
| Author | Araújo Neto, César Augusto de | |
| Author | Moreira, Edson Duarte | |
| Access date | 2022-05-06T18:40:36Z | |
| Available date | 2022-05-06T18:40:36Z | |
| Document date | 2022 | |
| Citation | DUARTE, Fernanda Gross et al. Incidence, aetiology and serotype coverage for pneumococcal vaccines of community-acquired pneumonia in adults: a population-based prospective active surveillance study in Brazil. BMJ Open, v. 12, n. 4, p. 1-11, 2022. | pt_BR |
| ISSN | 2044-6055 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/52570 | |
| Sponsorship | Pfizer, São Paulo, Brasil. Associação Obras Sociais Irmã Dulce e Pfizer. | pt_BR |
| Language | eng | pt_BR |
| Publisher | BMJ Publishing Group | pt_BR |
| Rights | open access | pt_BR |
| MeSH | Pneumonia | pt_BR |
| MeSH | Streptococcus pneumoniae | pt_BR |
| Subject in Portuguese | Pneumonia adquirida na comunidade | pt_BR |
| Subject in Portuguese | Incidência | pt_BR |
| Subject in Portuguese | Vacinas pneumocócicas | pt_BR |
| Subject in Portuguese | Distribuição de sorotipos | pt_BR |
| Subject in Portuguese | Streptococcus pneumoniae | pt_BR |
| Title | Incidence, aetiology and serotype coverage for pneumococcal vaccines of community-acquired pneumonia in adults: a population-based prospective active surveillance study in Brazil | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1136/bmjopen-2021-059824. | |
| Abstract | Objectives: To determine the incidence, aetiology and pneumococcal serotype distribution of community-acquired pneumonia (CAP) in Brazilian adults during a 2-year period. Design: Prospective population-based surveillance study. Setting: Patients from two emergency hospitals in Brazil were consecutively included in this study. Participants: A total of 111 adults aged 50 years and older with radiographically-confirmed CAP requiring an emergency department visit were prospectively enrolled between January 2018 and January 2020.
Main outcome measures: Incidence rates of CAP were calculated according to age and pathogen. Pathogens were identified by conventional microbiological methods. Additionally, a novel, Luminex-based serotype specific urinary antigen detection assay was used to detect serotypes included in pneumococcal vaccines.
Results: Mean age of participants was 64 years and 31% were aged ≥70 years. Aetiology was established in 61 (57%) patients; among identified cases, the most common pathogens were Streptococcus pneumoniae (42/61, 69%) and influenza (4/61, 7%). Among serotypes identified from the 42 cases of pneumococcal CAP, estimated coverage ranged by pneumococcal vaccine formulations from 47.6% (13-valent), 59.5% (20-valent, licenced in the USA only) and 71.4% (23-valent). In patients with CAP, 20-valent pneumococcal vaccine serotypes were identified 2.5 times more frequently than 10-valent pneumococcal vaccine serotypes (22.5% vs 9.0%). The incidence rate for CAP in adults aged ≥50 years was 20.1 per 10 000 person-years. In general, the incidence of CAP increased consistently with age, reaching 54.4 (95% CI 36.8 to -76.6) per 10 000 in adults 80 years or older. Conclusions: We observed a high burden of pneumococcal CAP among adults in Brazil. Despite the routine immunisation of children and high-risk adults against pneumococcal disease in the Brazilian national vaccination programme, a persistent burden of pneumococcal CAP caused by vaccine serotypes remains in this population. | pt_BR |
| Affilliation | Ministério da Saúde. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Ministério da Saúde. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Centro de Pesquisa Clínica. Obras Sociais Irma Dulce. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Pfizer Brasil. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Pfizer Inc. New York, NY, USA. | pt_BR |
| Affilliation | Pfizer Inc Pennsylvania. Collegeville, Pennsylvania, USA. | pt_BR |
| Affilliation | Pfizer Inc Pennsylvania. Collegeville, Pennsylvania, USA. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Ministério da Saúde. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Centro de Pesquisa Clínica. Obras Sociais Irma Dulce. Salvador, BA, Brasil. | pt_BR |
| Subject | Community-acquired pneumonia | pt_BR |
| Subject | Incidence | pt_BR |
| Subject | Pneumococcal vaccines | pt_BR |
| Subject | Serotype distribution | pt_BR |
| Subject | Streptococcus pneumoniae | pt_BR |
| DeCS | Pneumonia | pt_BR |
| DeCS | Incidência | pt_BR |
| DeCS | Vacinas Pneumocócicas | pt_BR |
| DeCS | Streptococcus pneumoniae | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
