| Author | Paixao, Enny S. | |
| Author | Wong, Kerry L. M. | |
| Author | Alves, Flavia Jôse Oliveira | |
| Author | Oliveira, Vinicius de Araújo | |
| Author | Silva, Thiago Cerqueira | |
| Author | Bertoldo Júnior, Juracy | |
| Author | Machado, Tales Mota | |
| Author | Pinto Junior, Elzo Pereira | |
| Author | Boaventura, Viviane S. | |
| Author | Penna, Gerson O. | |
| Author | Werneck, Guilherme Loureiro | |
| Author | Rodrigues, Laura C. | |
| Author | Pearce, Neil | |
| Author | Barreto, Mauricio L. | |
| Author | Barral Netto, Manoel | |
| Access date | 2022-05-09T19:21:09Z | |
| Available date | 2022-05-09T19:21:09Z | |
| Document date | 2022 | |
| Citation | PAIXÃO, Enny S. et al. CoronaVac vaccine is effective in preventing symptomatic and severe COVID‑19 in pregnant women in Brazil: a test‑negative case‑control study. BMC Medicine, v. 20, n. 146, p. 1-8, 2022. | pt_BR |
| ISSN | 1741-7015 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/52591 | |
| Sponsorship | Programa VigiVac Fiocruz. Programa “Fazer o bem faz bem”. Wellcome Trust. | pt_BR |
| Language | eng | pt_BR |
| Publisher | BMC | pt_BR |
| Rights | open access | pt_BR |
| MeSH | Vaccines | pt_BR |
| MeSH | COVID-19 | pt_BR |
| MeSH | SARS-CoV-2 | pt_BR |
| Subject in Portuguese | Eficácia da vacina | pt_BR |
| Subject in Portuguese | Vacina inativada | pt_BR |
| Subject in Portuguese | Mulheres grávidas | pt_BR |
| Subject in Portuguese | COVID-19 | pt_BR |
| Subject in Portuguese | SARS-CoV-2 | pt_BR |
| Title | CoronaVac vaccine is effective in preventing symptomatic and severe COVID‑19 in pregnant women in Brazil: a test‑negative case‑control study | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1186/s12916-022-02353-w | |
| Abstract | Background: More doses of CoronaVac have been administered worldwide than any other COVID-19 vaccine. However, the effectiveness of COVID-19 inactivated vaccines in pregnant women is still unknown. We estimated the vaccine effectiveness (VE) of CoronaVac against symptomatic and severe COVID-19 in pregnant women in Brazil. Methods: We conducted a test-negative design study in all pregnant women aged 18–49 years with COVID-19-related symptoms in Brazil from March 15, 2021, to October 03, 2021, linking records of negative and positive SARS-CoV-2 reverse transcription polymerase chain reaction (RT-PCR) tests to national vaccination records. We also linked records of test-positive cases with notifications of severe, hospitalised or fatal COVID-19. Using logistic regression, we estimated the adjusted odds ratio and VE against symptomatic COVID-19 and against severe COVID-19 by comparing vaccine status in test-negative subjects to test-positive symptomatic cases and severe cases. Results: Of the 19,838 tested pregnant women, 7424 (37.4%) tested positive for COVID-19 and 588 (7.9%) had severe disease. Only 83% of pregnant women who received the first dose of CoronaVac completed the vaccination scheme. A single dose of the CoronaVac vaccine was not effective at preventing symptomatic COVID-19. The effectiveness of two doses of CoronaVac was 41% (95% CI 27.1–52.2) against symptomatic COVID-19 and 85% (95% CI 59.5–94.8) against severe COVID-19. Conclusions: A complete regimen of CoronaVac in pregnant women was effective in preventing symptomatic COVID-19 and highly effective against severe illness in a setting that combined high disease burden and marked COVID-19-related maternal deaths. | pt_BR |
| Affilliation | London School of Hygiene and Tropical Medicine. London, UK / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil. | pt_BR |
| Affilliation | London School of Hygiene and Tropical Medicine. London, UK. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Ouro Preto. Ouro Preto, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Centro de Medicina Tropical da Universidade de Brasília. Escola de Governo Fiocruz Brasília. Brasília, DF, Brasil. | pt_BR |
| Affilliation | Universidade do Estado do Rio de Janeiro. Instituto de Medicina Social. Rio de Janeiro, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Estudos em Saúde Coletiva. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | London School of Hygiene and Tropical Medicine. London, UK / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil. | pt_BR |
| Affilliation | London School of Hygiene and Tropical Medicine. London, UK. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil. | pt_BR |
| Subject | Vaccine effectiveness | pt_BR |
| Subject | Inactivated vaccine | pt_BR |
| Subject | Pregnant women | pt_BR |
| Subject | COVID-19 | pt_BR |
| Subject | SARS-CoV-2 | pt_BR |
| Subject in Spanish | Eficacia de la vacuna | pt_BR |
| Subject in Spanish | Vacuna inactivada | pt_BR |
| Subject in Spanish | Mujeres embarazadas | pt_BR |
| Subject in Spanish | COVID-19 | pt_BR |
| Subject in Spanish | SARS-CoV-2 | pt_BR |
| Subject in French | Efficacité du vaccin | pt_BR |
| Subject in French | Vaccin inactivé | pt_BR |
| Subject in French | Femmes enceintes | pt_BR |
| Subject in French | COVID-19 | pt_BR |
| Subject in French | SRAS-CoV-2 | pt_BR |
| DeCS | Vacinas | pt_BR |
| DeCS | Vacinas de Produtos Inativados | pt_BR |
| DeCS | Gestantes | pt_BR |
| DeCS | COVID-19 | pt_BR |
| DeCS | SARS-CoV-2 | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
| xmlui.metadata.dc.subject.ods | 05 Igualdade de gênero | |
