| Author | Villela, Gilberto G. | |
| Author | Mello, Maria Isabel | |
| Access date | 2022-05-15T11:51:05Z | |
| Available date | 2022-05-15T11:51:05Z | |
| Document date | 1948 | |
| Citation | VILLELA, Gilberto G.; MELLO, Maria Isabel. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 46, n. 4, p. 1 - 7, 1948. | pt_BR |
| ISSN | 0074-0206 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/52678 | |
| Language | por | pt_BR |
| Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Ácido pteroíglutâmico | pt_BR |
| Subject in Portuguese | Peso e Fosfatase alcalina | pt_BR |
| Subject in Portuguese | Rim | pt_BR |
| Subject in Portuguese | Ação | pt_BR |
| Title | Ação do acido pteroílglutâmico sobre o peso e a fosfatase alcalina do rim | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1590/S0074-02761948000400007 | |
| Abstract | PGA when administered subcutaneously into normal mice in a single injection produces after 24 hours an affective increase of the total weight and a decrease of the "alkaline" phosphatase of the kidneys. Normal values based on 54 mice are reported and compared with those obtained from 88 mice injected with graded doses of PGA (0.5mg/Kg to 500mg/Kg body weight. The "alkaline" phosphatase was determined by a slight modification of the colorimetric method of king & Armstrong using disodium phenylphosphate as a substrate. It is suggested that the retention and precipitation of PGA in the renal tubuli could be responsible for the increased weight and decreased phosphatase activity of the kidneys. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Química. Divisão de Química e Farmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Química. Divisão de Química e Farmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| e-ISSN | 1678-8060 | |
