| Author | Godoy, Raquel Soares Maia | |
| Author | Barbosa, Renata Cristina | |
| Author | Vasconcelos, Thamara Figueiredo Procópio | |
| Author | Lorena, Marcelo Jacobs | |
| Author | Martins, Gustavo Ferreira | |
| Access date | 2022-06-08T18:12:13Z | |
| Available date | 2022-06-08T18:12:13Z | |
| Document date | 2021 | |
| Citation | GODOY, Raquel Soares Maia et al. FMRF-related peptides in Aedes aegypti midgut: neuromuscular connections and enteric nervous system. Cell Tissue Res., v. 385, p. 585–602, 2021. doi.org/10.1007/s00441-021-03462-3 | pt_BR |
| ISSN | 0302-766X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/53127 | |
| Language | eng | pt_BR |
| Publisher | Springer | pt_BR |
| Rights | restricted access | pt_BR |
| Title | FMRF-related peptides in Aedes aegypti midgut: neuromuscular connections and enteric nervous system | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1007/s00441-021-03462-3 | |
| Abstract | FMRFamide-related peptides (FaRPs) are a class of neuropeptides that participate in a variety of physiological processes in invertebrates. They occur in nerves of stomatogastric ganglia and enteroendocrine cells of the insect digestive tract, where they may control muscle functions. However, their direct involvement in muscle function has never been shown in situ. We studied the relationship between FaRPs and midgut muscle during larval–pupal transition of the mosquito Aedes aegypti. In late L4, FaRP-positive neuronal extensions attach to the bundles of the external circular muscle layer, and muscle stem cells start to undergo mitosis in the internal circular layer. Thereafter, the external muscle layer degenerates, disappearing during early pupal development, and is completely absent in the adult mosquito. Our results indicate that FaRP-based neural signals are involved in the reorganization of the muscle fibers of the mosquito midgut during the larval–pupal transition. In addition to confirming FaRP involvement in muscle function, we show that the mosquito midgut muscles are largely innervated, and that circular and longitudinal muscle have specific neuron bodies associated with them. | pt_BR |
| Affilliation | Universidade Federal de Viçosa. Departamento de Biologia Geral. Viçosa, MG, Brazil/Fundação Oswaldo Cruz. Instituto René Rachou, Fiocruz. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Viçosa. Departamento de Biologia Geral. Viçosa, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Departamento de Bioquímica e Fisiologia. Recife, PE, Brazil | pt_BR |
| Affilliation | The W. Harry Feinstone Department of Molecular Microbiology and Immunology /Johns Hopkins Malaria Research Institute. Bloomberg School of Public Health. Johns Hopkins University. Baltimore, MD, USA | pt_BR |
| Affilliation | Universidade Federal de Viçosa. Departamento de Biologia Geral. Viçosa, MG, Brazil | pt_BR |
| Subject | Insects | pt_BR |
| Subject | Midgut neurons | pt_BR |
| Subject | Visceral muscle | pt_BR |
| Subject | Neuropeptides | pt_BR |
| Subject | Metamorphosis | pt_BR |
