| Author | Moraes, Flávia Maciel de | |
| Author | Souza, Julia Werneck Paulino Soares de | |
| Author | Alves, Letícia Pires | |
| Author | Siqueira, Milena Ferreira Ribeiro de | |
| Author | Santos, Ana Paula Aguiar dos | |
| Author | Berardo, Mariana Monteiro de Carvalho | |
| Author | Granja, Marcelo Gomes | |
| Author | Faria Neto, Hugo Caire de Castro | |
| Access date | 2022-06-13T12:01:50Z | |
| Available date | 2022-06-13T12:01:50Z | |
| Document date | 2022 | |
| Citation | MORAES, Flávia Maciel de et al. SARS-CoV-2 Infection and Possible Neonatal Neurological Outcomes: A Literature Review. Viruses, v. 14, 1037, p. 1 - 13, May 2022.. | pt_BR |
| ISSN | 1999-4915 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/53221 | |
| Language | eng | pt_BR |
| Publisher | MDPI | pt_BR |
| Rights | open access | |
| Subject in Portuguese | SARS-CoV-2 | pt_BR |
| Subject in Portuguese | Resultados neurológicos | pt_BR |
| Subject in Portuguese | Infecções neonatais | pt_BR |
| Subject in Portuguese | Cérebro | pt_BR |
| Title | SARS-CoV-2 Infection and Possible Neonatal Neurological Outcomes: A Literature Review | pt_BR |
| Type | Article | |
| DOI | 10.3390/ v14051037 | |
| Abstract | The virus responsible for COVID-19 is designated “severe acute respiratory syndrome
coronavirus 2” (SARS-CoV-2), a highly transmissible and pathogenic coronavirus. Although people
of all ages are susceptible to SARS-CoV-2 infection, clinical manifestations may vary with age. The
response of neonates to SARS-CoV-2 infection or exposure differs from that of children and adults.
Encephalitis due to viral infections in the central nervous system (CNS) and childhood multisystem
inflammatory syndrome (MIS-C) are some of the possible neonatal consequences of SARS-CoV-2
infection. This review aims to verify possible neonatal neurological outcomes after SARS-CoV-2
infection. Overall, the cellular and molecular basis of the neurological sequelae of SARS-CoV-2 in
neonates remains unclear, and attempts to elucidate the pathophysiology of COVID-19 involve a
comparison with the mechanism of other viral diseases. There are a considerable number of case
reports in the literature exploring neurological outcomes in the neonatal period. In this review, we
present possible effects of SARS-CoV-2 in neonates, emphasizing the importance of monitoring this
group. The mechanisms of SARS-CoV-2 entry into the CNS have not yet been fully elucidated, and the
potential severity of SARS-CoV-2 infection in neonates, as well as the possible short- and long-term
neurological sequelae, remain unclear. | pt_BR |
| Affilliation | Universidade Federal do Estado do Rio de Janeiro—UNIRIO. Programa de Pós-Graduação em Biologia Molecular e Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Estácio de Sá. Instituto de Educação Médica—IDOMED. Escola de Medicina. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Estado do Rio de Janeiro—UNIRIO. Programa de Pós-Graduação em Biologia Molecular e Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto Biomédico. Faculdade de Biomedicina. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Técnico-Educacional Souza Marques. Escola de Medicina. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Estácio de Sá. Instituto de Educação Médica—IDOMED. Escola de Medicina. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | SARS-CoV-2 | pt_BR |
| Subject | Neurological outcomes | pt_BR |
| Subject | Neonatal infections | pt_BR |
| Subject | Brain | pt_BR |
