| Author | Gonçalves, Pamela Rosa | |
| Author | Gomes, Flávia Lima Ribeiro | |
| Author | Ribeiro, Cláudio Tadeu Daniel | |
| Access date | 2022-06-15T17:43:56Z | |
| Available date | 2022-06-15T17:43:56Z | |
| Document date | 2022 | |
| Citation | GONÇALVES, Pamela Rosa et al. Malaria Related Neurocognitive Deficits and Behavioral Alterations. Frontiers in Cellular and Infection Microbiology, v. 12, Article 829413, Feb. 2022. | pt_BR |
| ISSN | 2235-2988 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/53280 | |
| Language | eng | pt_BR |
| Publisher | Frontiers Media | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Malária grave | pt_BR |
| Subject in Portuguese | Malária não grave | pt_BR |
| Subject in Portuguese | Déficits neurocognitivos | pt_BR |
| Subject in Portuguese | Alterações comportamentais | pt_BR |
| Subject in Portuguese | Malária murina | pt_BR |
| Title | Malaria Related Neurocognitive Deficits and Behavioral Alterations | pt_BR |
| Type | Article | |
| DOI | 10.3389/fcimb.2022.829413 | |
| Abstract | Typical of tropical and subtropical regions, malaria is caused by protozoa of the genus
Plasmodium and is, still today, despite all efforts and advances in controlling the disease, a
major issue of public health. Its clinical course can present either as the classic episodes of
fever, sweating, chills and headache or as nonspecific symptoms of acute febrile
syndromes and may evolve to severe forms. Survivors of cerebral malaria, the most
severe and lethal complication of the disease, might develop neurological, cognitive and
behavioral sequelae. This overview discusses the neurocognitive deficits and behavioral
alterations resulting from human naturally acquired infections and murine experimental
models of malaria. We highlighted recent reports of cognitive and behavioral sequelae of
non-severe malaria, the most prevalent clinical form of the disease worldwide. These
sequelae have gained more attention in recent years and therapies for them are required
and demand advances in the understanding of neuropathogenesis. Recent studies using
experimental murine models point to immunomodulation as a potential approach to
prevent or revert neurocognitive sequelae of malaria. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brasil / Colégio Pedro II. Laboratório de Biologia. Campus Duque de Caxias. Duque de Caxias, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária / Ministério da Sáude. Secretaria de Vigilância em Saúde. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária / Ministério da Sáude. Secretaria de Vigilância em Saúde. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Severe malaria | pt_BR |
| Subject | Non-severe malaria | pt_BR |
| Subject | Neurocognitive deficits | pt_BR |
| Subject | Behavioral alterations | pt_BR |
| Subject | Murine malaria | pt_BR |
