| Author | Brasiel, Poliana Guiomar de Almeida | |
| Author | Guimarães, Fernanda Verdini | |
| Author | Silva, Patrícia Machado Rodrigues e | |
| Author | Bou-Habib, Dumith Chequer | |
| Author | Carvalho, Vinicius de Frias | |
| Access date | 2022-06-15T18:03:40Z | |
| Available date | 2022-06-15T18:03:40Z | |
| Document date | 2022 | |
| Citation | BRASIEL, Poliana Guiomar de Almeida et al. Therapeutic Efficacy of Flavonoids in Allergies: A Systematic Review of Randomized Controlled Trials. Journal of Immunology Research, V.2022, Article ID 8191253, p. 1 - 9, , 2022. | pt_BR |
| ISSN | 1740-2530 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/53281 | |
| Language | eng | pt_BR |
| Publisher | Hindawi | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Eficácia Terapêutica | pt_BR |
| Subject in Portuguese | Flavonóides | pt_BR |
| Subject in Portuguese | Alergias | pt_BR |
| Subject in Portuguese | Revisão Sistemática | pt_BR |
| Subject in Portuguese | Ensaios Controlados Randomizados | pt_BR |
| Title | Therapeutic Efficacy of Flavonoids in Allergies: A Systematic Review of Randomized Controlled Trials | pt_BR |
| Type | Article | |
| DOI | 10.1155/2022/8191253 | |
| Abstract | Objective. To assess the clinical efficacy of flavonoid supplements on allergic diseases. Design. Systematic review. Data Sources.
MEDLINE/PubMed, Scopus, Web of Science, and Embase databases were searched from inception to September 2021.
Eligibility Criteria for Selecting Studies. Eligible study designs were randomized controlled trials that investigated the effect of
flavonoids applied to allergic diseases. Results. This review included 15 randomized controlled trials, including allergic rhinitis/
cedar pollinosis (n = 10), asthma (n = 3), and atopic dermatitis (n = 2). A total of 990 participants aged 6 to 69 years were
included in these studies. Globally, 12 studies (80%) revealed some benefits of flavonoids (isolate or combined with other
compounds) in allergic patients, while three studies (20%) reported no statistically significant impact on symptom scores and/
or lung function. No severe adverse events related to treatment were reported. According to the GRADE system, the outcomes
evaluated were of low to moderate quality of evidence. Conclusions. Overall, this review suggests that the administration of
flavonoids may provide a viable strategy for mitigating allergic symptoms. Future trials with high methodological quality are
needed to establish definitive conclusions. This trial is registered with PROSPERO registration no. CRD42021237403. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Ri de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Therapeutic Efficacy | pt_BR |
| Subject | Flavonoids | pt_BR |
| Subject | Allergies | pt_BR |
| Subject | Systematic Review | pt_BR |
| Subject | Randomized Controlled Trials | pt_BR |
