| Author | Ferreira, Tainá Neves | |
| Author | Brazil, Reginaldo Peçanha | |
| Author | McDowell, Mary Ann | |
| Author | Cunha Júnior, Edézio Ferreira | |
| Author | Costa, Paulo Roberto Ribeiro | |
| Author | Daher Neto, Chaquip | |
| Author | Santos, Eduardo Caio Torres | |
| Author | Genta, Fernando Ariel | |
| Access date | 2022-06-21T20:47:41Z | |
| Available date | 2022-06-21T20:47:41Z | |
| Document date | 2022 | |
| Citation | FERREIRA, Tainá Neves et al. Effects of anti-Leishmania compounds in the behavior of the sand fly vector Lutzomyia longipalpis. Pest Management Science, v. 78, p. 2792-2805, 2022. | pt_BR |
| ISSN | 1526-498X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/53410 | |
| Language | eng | pt_BR |
| Publisher | John Wiley & Sons | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Mosca de areia | pt_BR |
| Subject in Portuguese | Isca de açúcar | pt_BR |
| Subject in Portuguese | Leishmania | pt_BR |
| Subject in Portuguese | Repelente | pt_BR |
| Subject in Portuguese | Dissuasão | pt_BR |
| Subject in Portuguese | Lutzomyia | pt_BR |
| Title | Effects of anti-Leishmania compounds in the behavior of the sand fly vector Lutzomyia longipalpis | pt_BR |
| Type | Article | |
| DOI | 10.1002/ps.6900 | |
| Abstract | BACKGROUND: Leishmaniasis is an infectious parasitic disease caused by pathogens of the genus Leishmania transmitted
through the bite of adult female sand flies. To reduce case numbers, it is necessary to combine different control approaches,
especially those aimed at the sand fly vectors. Innovative forms of control with the use of attractive sugar baits explored the
fact that adult sand flies need to feed on sugars of plant origin. Leishmania parasites develop in the gut of sand flies, interacting
with the sugars in the diet of adults. Recent studies have shown that sugar baits containing plant-derived compounds can
reduce sand fly survival, the number of parasites per gut, and the percentage of infected sand flies. Several synthetic compounds
produced from naphthoquinones and pterocarpans have anti-parasitic activity on Leishmania amazonensis and/or
Leishmania infantum in cell culture. This work aimed to assess the inclusion of these compounds in sugar baits for blocking
transmission, targeting the development of the Leishmania parasite inside the sand fly vector.
RESULTS: We evaluated the attractant or repellent properties of these compounds, as well as of the reference compound N,N0-
diethyl-m-toluamide (DEET), in sugar baits. We also observed changes in feeding preference caused by these compounds, looking
for anti-feeding or stimulation of ingestion. Pterocarpanquinone L4 and pentamidine showed attractant and repellent
properties, respectively.
CONCLUSION: Based on the effects in feeding preference and intake volume, pterocarpanquinone L6, and the pyrazole-derived
compound P8 were chosen as the most promising compounds for the future development of anti-Leishmania sugar baits.
© 2022 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica e Fisiologia de Insetos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Doenças Parasitárias. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame. IN, USA. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Unidade Integrada de Pesquisa em Produtos Bioativos e Biociências. Laboratório de Imunoparasitologia. Campus Macaé, Rj, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Pesquisas de Produtos Naturais. Laboratório de Química Bioorgânica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Laboratório de Química. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Laboratório de Bioquímica de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica e Fisiologia de Insetos. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro, Brasil. | pt_BR |
| Subject | Sand fly | pt_BR |
| Subject | Sugar bait | pt_BR |
| Subject | Leishmania | pt_BR |
| Subject | Repellent | pt_BR |
| Subject | Deterrent | pt_BR |
| Subject | Lutzomyia | pt_BR |
