| Author | Morgado, Sergio | |
| Author | Vicente, Ana Carolina | |
| Access date | 2022-06-27T19:35:29Z | |
| Available date | 2022-06-27T19:35:29Z | |
| Document date | 2022 | |
| Citation | MORGADO, Sergio; VICENTE, Ana Carolina. Diversity and distribution of Type VI Secretion System gene clusters in bacterial plasmids. Scientific Reports, v. 12, 8249, p. 1 - 9, 2022. | pt_BR |
| ISSN | 2045-2322 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/53545 | |
| Language | eng | pt_BR |
| Publisher | Nature Portfolio | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Diversidade e distribuição | pt_BR |
| Subject in Portuguese | Agrupamentos de genes | pt_BR |
| Subject in Portuguese | Sistema de Secreção VI | pt_BR |
| Subject in Portuguese | Plasmídeos bacterianos | pt_BR |
| Title | Diversity and distribution of Type VI Secretion System gene clusters in bacterial plasmids | pt_BR |
| Type | Article | |
| DOI | 10.1038/s41598-022-12382-3 | |
| Abstract | Type VI Secretion System (T6SS) is a nanomolecular apparatus that allows the delivery of effector
molecules through the cell envelope of a donor bacterium to prokaryotic and/or eukaryotic cells,
playing a role in the bacterial competition, virulence, and host interaction. T6SS is patchily distributed
in bacterial genomes, suggesting an association with horizontal gene transfer (HGT). In fact, T6SS
gene loci are eventually found within genomic islands (GIs), and there are some reports in plasmids
and integrative and conjugative elements (ICEs). The impact that T6SS may have on bacteria fitness
and the lack of evidence on its spread mechanism led us to question whether plasmids could represent
a key mechanism in the spread of T6SS in bacteria. Therefore, we performed an in-silico analysis to
reveal the association between T6SS and plasmids. T6SS was mined on 30,660 plasmids from NCBI
based on the presence of at least six T6SS core proteins. T6SS was identified in 330 plasmids, all
belonging to the same type (
T6SSi), mainly in Proteobacteria (328/330), particularly in Rhizobium and
Ralstonia. Interestingly, most genomes carrying T6SS-harboring plasmids did not encode T6SS in their
chromosomes, and, in general, chromosomal and plasmid T6SSs did not form separate clades. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microorganimos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microorganimos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Diversity and distribution | pt_BR |
| Subject | Type VI Secretion System | pt_BR |
| Subject | Gene clusters | pt_BR |
| Subject | Bacterial plasmids | pt_BR |
| xmlui.metadata.dc.subject.ods | 10 Redução das desigualdades | |
