| Author | Monteiro, Guilherme Paz | |
| Author | Melo, Roberta Torres de | |
| Author | Guidotti-Takeuchi, Micaela | |
| Author | Dumont, Carolyne Ferreira | |
| Author | Ribeiro, Rosanne Aparecida Capanema | |
| Author | Guerra, Wendell | |
| Author | Ramos, Luana Munique Sousa | |
| Author | Paixão, Drielly Aparecida | |
| Author | Santos, Fernanda Aparecida Longato dos | |
| Author | Rodrigues, Dália dos Prazeres | |
| Author | Boleij, Peter | |
| Author | Hoepers, Patrícia Giovana | |
| Author | Rossi, Daise Aparecida | |
| Access date | 2022-06-27T19:59:39Z | |
| Available date | 2022-06-27T19:59:39Z | |
| Document date | 2022 | |
| Citation | MONTEIRO, Guilherme Paz et al. A Ternary Copper (II) Complex with 4-Fluorophenoxyacetic Acid Hydrazide in Combination with Antibiotics Exhibits Positive Synergistic Effect against Salmonella Typhimurium. Antibiotics, v. 11, 388, p. 1 - 17, Mar. 2022. | pt_BR |
| ISSN | 2079-6382 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/53546 | |
| Language | eng | pt_BR |
| Publisher | MDPI | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Segurança alimentar | pt_BR |
| Subject in Portuguese | Resistência a vários medicamentos | pt_BR |
| Subject in Portuguese | Salmonelose | pt_BR |
| Title | A Ternary Copper (II) Complex with 4-Fluorophenoxyacetic Acid Hydrazide in Combination with Antibiotics Exhibits Positive Synergistic Effect against Salmonella Typhimurium | pt_BR |
| Type | Article | |
| DOI | 10.3390/ antibiotics11030388 | |
| Abstract | Salmonella spp. continues to figure prominently in world epidemiological registries as
one of the leading causes of bacterial foodborne disease. We characterised 43 Brazilian lineages
of Salmonella Typhimurium (ST) strains, characterized drug resistance patterns, tested copper (II)
complex as control options, and proposed effective antimicrobial measures. The minimum inhibitory
concentration was evaluated for seven antimicrobials, isolated and combined with the
copper (II) complex [Cu(4-FH)(phen)(ClO4)2] (4-FH = 4-fluorophenoxyacetic acid hydrazide and
phen = 1,10-phenanthroline), known as DRI-12, in planktonic and sessile ST. In parallel, 42 resistance
genes were screened (PCR/microarray). All strains were multidrug resistant (MDR). Resistance to carbapenems
and polymyxins (86 and 88%, respectively) have drawn attention to the emergence of the
problem in Brazil, and resistance is observed also to CIP and CFT (42 and 67%, respectively), the drugs
of choice in treatment. Resistance to beta-lactams was associated with the genes blaTEM/blaCTX-M in
39% of the strains. Lower concentrations of DRI-12 (62.7 mg/L, or 100 M) controlled planktonic and
sessile ST in relation to AMP/SUL/TET and AMP/SUL/TET/COL, respectively. The synergistic
effect provided by DRI-12 was significant for COL/CFT and COL/AMP in planktonic and sessile ST,
respectively, and represents promising alternatives for the control of MDR ST. | pt_BR |
| Affilliation | Universidade Federal de Uberlândia. Laboratório de Epidemiologia Molecular. Uberlândia, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Uberlândia. Laboratório de Epidemiologia Molecular. Uberlândia, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Uberlândia. Laboratório de Epidemiologia Molecular. Uberlândia, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Uberlândia. Laboratório de Epidemiologia Molecular. Uberlândia, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Uberlândia. Laboratório de Epidemiologia Molecular. Uberlândia, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Uberlândia. Instituto de Química. Uberlândia, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Uberlândia. Instituto de Química. Uberlândia, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Uberlândia. Instituto de Química. Uberlândia, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Uberlândia. Laboratório de Epidemiologia Molecular. Uberlândia, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Enterobactérias. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Check-Points B.V., 6709 PD Wageningen, The Netherlands. | pt_BR |
| Affilliation | Universidade Federal de Uberlândia. Programa de Pós-Graduação em Ciência Veterinária. Uberlândia, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Uberlândia. Laboratório de Epidemiologia Molecular. Uberlândia, MG, Brasil. | pt_BR |
| Subject | Food safety | pt_BR |
| Subject | Multi drug resistance (MDR) | pt_BR |
| Subject | Salmonellosis | pt_BR |
| xmlui.metadata.dc.subject.ods | 02 Fome zero e agricultura sustentável | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
