| Author | Bourhy, Lena | |
| Author | Mazeraud, Aurélien | |
| Author | Bozza, Fernando A. | |
| Author | Turc, Guillaume | |
| Author | Lledo, Pierre-Marie | |
| Author | Sharshar, Tarek | |
| Access date | 2022-06-27T23:34:05Z | |
| Available date | 2022-06-27T23:34:05Z | |
| Document date | 2022 | |
| Citation | BOURHY, Lena et al. Neuro-Inflammatory Response and Brain-Peripheral Crosstalk in Sepsis and Stroke. Frontiers in Immunology, v. 13, p. 1-10, 2022. | pt_BR |
| ISSN | 1664-3224 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/53553 | |
| Language | eng | pt_BR |
| Publisher | Frontiers Media | pt_BR |
| Rights | open access | pt_BR |
| Title | Neuro-Inflammatory Response and Brain-Peripheral Crosstalk in Sepsis and Stroke | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.3389/fimmu.2022.834649 | |
| Abstract | Despite recent therapeutic advances, ischemic stroke is still a leading cause of death and disability. There is renewed attention on peripheral inflammatory signaling as a way of modulating the post-ischemic neuro-inflammatory process. The immune-brain crosstalk has long been the focus for understanding the mechanisms of sickness behavior, which is an adaptive autonomic, neuroendocrine, and behavioral response to a peripheral inflammation. It is mediated by humoral and neural pathways that mainly involve the circumventricular organs and vagal nerve, respectively. In this review we address the question of how sepsis and stroke can dysregulate this adaptive response, notably by impairing the central integration of peripheral signaling, but also by efferent control of the immune response. We highlight the potential role of gut-brain and brain-spleen signaling in stroke. | pt_BR |
| Affilliation | Institut Pasteur. Université de Paris. Centre National de Recherche Scientifique. Unité Mixte de Recherche (CNRS UMR) 3571. Perception and Memory Unit. Paris, France. | pt_BR |
| Affilliation | Institut Pasteur. Université de Paris. Centre National de Recherche Scientifique. Unité Mixte de Recherche (CNRS UMR) 3571. Perception and Memory Unit. Paris, France / Université de Paris. Groupe Hospitalier Universitaire (GHU) Paris Psychiatrie et Neurosciences. Neuro-Anesthesiology and Intensive Care Medicine. Paris, France. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | Université de Paris. GHU Paris Psychiatrie et Neurosciences. Department of Neurology. Paris, France. | pt_BR |
| Affilliation | Institut Pasteur. Université de Paris. Centre National de Recherche Scientifique. Unité Mixte de Recherche (CNRS UMR) 3571. Perception and Memory Unit. Paris, France. | pt_BR |
| Affilliation | Université de Paris. Groupe Hospitalier Universitaire (GHU) Paris Psychiatrie et Neurosciences. Neuro-Anesthesiology and Intensive Care Medicine. Paris, France. | pt_BR |
| Subject | Immune response | pt_BR |
| Subject | Ischemic stroke | pt_BR |
| Subject | Neuromodulation | pt_BR |
| Subject | Sepsis | pt_BR |
| Subject | Sickness behavior | pt_BR |
