| Author | Fonseca, Érica L. | |
| Author | Vicente, Ana Carolina | |
| Access date | 2022-06-28T16:49:48Z | |
| Available date | 2022-06-28T16:49:48Z | |
| Document date | 2022 | |
| Citation | FONSECA, Érica L.; VICENTE, Ana Carolina. Integron Functionality and Genome Innovation: An Update on the Subtle and Smart Strategy of Integrase and Gene Cassette Expression Regulation. Microorganisms, v. 10, 224, p. 1 - 34, 2022. | pt_BR |
| ISSN | 2076-2607 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/53555 | |
| Language | eng | pt_BR |
| Publisher | MDPI | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Integron | pt_BR |
| Subject in Portuguese | Transcrição | pt_BR |
| Subject in Portuguese | Regulador global | pt_BR |
| Subject in Portuguese | Resposta SOS | pt_BR |
| Subject in Portuguese | Adaptação | pt_BR |
| Subject in Portuguese | Interferência de transcrição | pt_BR |
| Subject in Portuguese | Acoplamento de tradução | pt_BR |
| Subject in Portuguese | Atenuação de tradução | pt_BR |
| Subject in Portuguese | Expressão de cassete gênica | pt_BR |
| Title | Integron Functionality and Genome Innovation: An Update on the Subtle and Smart Strategy of Integrase and Gene Cassette Expression Regulation | pt_BR |
| Type | Article | |
| DOI | 10.3390/ microorganisms10020224 | |
| Abstract | Integrons are considered hot spots for bacterial evolution, since these platforms allow
one-step genomic innovation by capturing and expressing genes that provide advantageous novelties,
such as antibiotic resistance. The acquisition and shuffling of gene cassettes featured by integrons
enable the population to rapidly respond to changing selective pressures. However, in order to avoid
deleterious effects and fitness burden, the integron activity must be tightly controlled, which happens
in an elegant and elaborate fashion, as discussed in detail in the present review. Here, we aimed to
provide an up-to-date overview of the complex regulatory networks that permeate the expression and
functionality of integrons at both transcriptional and translational levels. It was possible to compile
strong shreds of evidence clearly proving that these versatile platforms include functions other than
acquiring and expressing gene cassettes. The well-balanced mechanism of integron expression is
intricately related with environmental signals, host cell physiology, fitness, and survival, ultimately
leading to adaptation on the demand. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Integron | pt_BR |
| Subject | Transcription | pt_BR |
| Subject | Global regulator | pt_BR |
| Subject | SOS response | pt_BR |
| Subject | Adaptation | pt_BR |
| Subject | Transcription interference | pt_BR |
| Subject | Translation coupling | pt_BR |
| Subject | Translation attenuation | pt_BR |
| Subject | Gene cassette expression | pt_BR |
