| Author | Fumagalli, Marcilio Jorge | |
| Author | Castro-Jorge, Luiza Antunes | |
| Author | Fraga-Silva, Thais Fernanda de Campos | |
| Author | de Azevedo, Patrick Orestes | |
| Author | Capato, Carlos Fabiano | |
| Author | Rattis, Bruna Amanda Cruz | |
| Author | Hojo-Souza, Natália Satchiko | |
| Author | Floriano, Vitor Gonçalves | |
| Author | de Castro, Julia Teixeira | |
| Author | Ramos, Simone Gusmão | |
| Author | da Fonseca, Benedito Antônio Lopes | |
| Author | Bonato, Vânia Luiza Deperon | |
| Author | Gazzinelli, Ricardo Tostes | |
| Author | Figueiredo, Luiz Tadeu Moraes. | |
| Access date | 2022-06-28T17:52:41Z | |
| Available date | 2022-06-28T17:52:41Z | |
| Document date | 2021 | |
| Citation | FUMAGALLI, Marcilio Jorge et al. Protective Immunity against Gamma and Zeta Variants after Inactivated SARS-CoV-2 Virus Immunization. Viruses ; v. 13, n. 12, 2021, 2440. doi: 10.3390/v13122440 | pt_BR |
| ISSN | 1999-4915 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/53562 | |
| Language | eng | pt_BR |
| Publisher | MDPI | pt_BR |
| Rights | open access | pt_BR |
| Title | Protective Immunity against Gamma and Zeta Variants after Inactivated SARS-CoV-2 Virus Immunization. | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.3390/v13122440 | |
| Abstract | The persistent circulation of SARS-CoV-2 represents an ongoing global threat due to the emergence of new viral variants that can sometimes evade the immune system of previously exposed or vaccinated individuals. We conducted a follow-up study of adult individuals that had received an inactivated SARS-CoV-2 vaccine, evaluating antibody production and neutralizing activity over a period of 6 months. In addition, we performed mice immunization with inactivated SARS-CoV-2, and evaluated the immune response and pathological outcomes against Gamma and Zeta variant infection. Vaccinated individuals produced high levels of antibodies with robust neutralizing activity, which was significantly reduced against Gamma and Zeta variants. Production of IgG anti-S antibodies and neutralizing activity robustly reduced after 6 months of vaccination. Immunized mice demonstrated cellular response against Gamma and Zeta variants, and after viral infection, reduced viral loads, IL-6 expression, and histopathological outcome in the lungs. TNF levels were unchanged in immunized or not immunized mice after infection with the Gamma variant. Furthermore, serum neutralization activity rapidly increases after infection with the Gamma and Zeta variants. Our data suggest that immunization with inactivated WT SARS-CoV-2 induces a promptly responsive cross-reactive immunity response against the Gamma and Zeta variants, reducing COVID-19 pathological outcomes. | pt_BR |
| Affilliation | Virology Research Center. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, Saulo, Brazil. | pt_BR |
| Affilliation | Basic and Applied Immunology Program. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, SP, Brazil. | pt_BR |
| Affilliation | Virology Research Center. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, Saulo, Brazil. | pt_BR |
| Affilliation | Department of Biochemistry and Immunology. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, SP, Brazil. | pt_BR |
| Affilliation | Department of Biochemistry and Immunology. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, SP, Brazil. | pt_BR |
| Affilliation | Virology Research Center. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, Saulo, Brazil. | pt_BR |
| Affilliation | Department of Pathology. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, SP, Brazil. | pt_BR |
| Affilliation | Immunopathology Laboratory. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Virology Research Center. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, SP, Brazil. | pt_BR |
| Affilliation | Immunopathology Laboratory. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Virology Research Center. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, SP, Brazil. | pt_BR |
| Affilliation | Department of Pathology. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, SP, Brazil. | pt_BR |
| Affilliation | Basic and Applied Immunology Program. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, SP, Brazil. | pt_BR |
| Affilliation | Department of Biochemistry and Immunology. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, SP, Brazil. | pt_BR |
| Subject | SARS-CoV-2 | pt_BR |
| Subject | Gamma variant | pt_BR |
| Subject | Zeta variant | pt_BR |
| Subject | cross-protection | pt_BR |
| Subject | inactivated vaccine | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
