| Author | Villar, Livia Melo | |
| Author | Fraga, Ketlyn Araujo | |
| Author | Mendonça, Ana Carolina da Fonseca | |
| Author | Miguel, Juliana Custódio | |
| Author | Silva, Elisangela Ferreira da | |
| Author | Barbosa, Jakeline Ribeiro | |
| Author | Sousa, Paulo Sérgio Fonseca de | |
| Author | Lewis-Ximenez, Lia Laura | |
| Author | Mello, Francisco Campello do Amaral | |
| Access date | 2022-06-28T17:54:48Z | |
| Available date | 2022-06-28T17:54:48Z | |
| Document date | 2022 | |
| Citation | VILLAR, Livia Melo et al. Serological and molecular characterization of hepatitis B virus infection in chronic kidney disease patients from Rio de Janeiro, Brazil. The Brazilian Journal of Infection Diseases, v. 26, n.3, p. 1 - 8, 2022. | pt_BR |
| ISSN | 1413-8670 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/53563 | |
| Language | eng | pt_BR |
| Publisher | Elsevier España | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Hepatite B | pt_BR |
| Subject in Portuguese | Epidemiologia | pt_BR |
| Subject in Portuguese | Variabilidade genética | pt_BR |
| Subject in Portuguese | Doença renal crônica | pt_BR |
| Subject in Portuguese | Hemodiálise | pt_BR |
| Title | Serological and molecular characterization of hepatitis B virus infection in chronic kidney disease patients from Rio de Janeiro, Brazil | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.bjid.2022.102371 | |
| Abstract | Chronic kidney disease (CKD) patients undergoing hemodialysis (HD) are more vulnerable to
blood-borne viral infections due to frequent invasive procedures. Hepatitis B virus (HBV)
infection in this cohort of patients has been a matter of concern worldwide. The objective of
this cross-sectional study was to evaluate the frequency of serological markers for hepatitis
B, and the occurrence of overt and occult HBV infection (OBI) and its molecular characterization
in serum samples from 644 CKD patients in HD units located in Rio de Janeiro, Brazil,
from 2013 to 2017. HBV DNA was investigated in HBsAg reactive and “anti-HBc alone” samples
to determine infecting genotypes and genetic relatedness between sequences. The prevalence
of serological markers HBsAg+, anti-HBc alone, anti-HBc+/anti-HBs+, anti-HBs+, anti-
HBc/anti-HBs/HBsAg were 5.9%, 2.8%, 30.7%, 26.6%, 34.0%, respectively. HBV DNA was
detected in 39.5% (15/38) of the HBsAg+ and in 5/18 (27.8%) of the “anti-HBc alone” individuals,
indicating a high prevalence of OBI within this group. We found a higher prevalence of
HBV/A1 (65%), followed by HBV/D3 (20%), and HBV/A2 (15%). BayesianMCC tree with a highly
supported clade, genetic distance comparison, and identical nucleotide sequences suggested
a nosocomial spread of HBV in some units. The high prevalence of HBV infection and low
number of individuals immune to infection reinforces the need for vaccination in this group.
The presence of closely related strains in the same HD unit reinforces the importance of continuous
improvement of safety control measures and laboratory surveillance of serological
markers to prevent the risk of infection and transmission of HBV. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Hepatitis B | pt_BR |
| Subject | Epidemiology | pt_BR |
| Subject | Genetic variability | pt_BR |
| Subject | Chronic kidney disease | pt_BR |
| Subject | Hemodialysis | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
