| Author | Scovino, Aline Miranda | |
| Author | Totino, Paulo Renato Rivas | |
| Author | Morrot, Alexandre | |
| Access date | 2022-06-30T21:09:23Z | |
| Available date | 2022-06-30T21:09:23Z | |
| Document date | 2022 | |
| Citation | SCOVINO, Aline Miranda; TOTINO, Paulo Renato Rivas; MORROT, Alexandre. Eryptosis as a New Insight in Malaria Pathogenesis. Frontiers in Immunology, v. 13, Article 855795, p. 1 - 8, May 2022. | pt_BR |
| ISSN | 1664-3224 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/53604 | |
| Language | eng | pt_BR |
| Publisher | Frontiers Media | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Infecção por Plasmodium | pt_BR |
| Subject in Portuguese | Eriptose | pt_BR |
| Subject in Portuguese | Patogênese da malária | pt_BR |
| Subject in Portuguese | Imunopatologia | pt_BR |
| Subject in Portuguese | Anemia malárica grave | pt_BR |
| Title | Eryptosis as a New Insight in Malaria Pathogenesis | pt_BR |
| Type | Article | |
| DOI | 10.3389/fimmu.2022.855795 | |
| Abstract | Eryptosis is a programmed cell death-like process that occurs in red blood cells. Although
the red blood cells are anucleated, there are similarities between eryptosis and apoptosis,
such as increased calcium efflux, calpain activation, phosphatidylserine exposure, cell
blebbing and cell shrinkage. Eryptosis occurs physiologically in red blood cells, as a
consequence of the natural senescence process of these cells, but it can also be
stimulated in pathological situations such as metabolic syndromes, uremic syndromes,
polycythemia vera, anemias such as sickle cell anemia and thalassemia, and infectious
processes including Plasmodium infection. Infection-induced eryptosis is believed to
contribute to damage caused by Plasmodium, but it’s still a topic of debate in the
literature. In this review, we provided an overview of eryptosis mechanisms and its
possible pathogenic role in malaria. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | Plasmodium infection | pt_BR |
| Subject | Eryptosis | pt_BR |
| Subject | Malaria pathogenesis | pt_BR |
| Subject | Immunopathology | pt_BR |
| Subject | Severe malarial anemia | pt_BR |
