| Author | Moura, Silvia Beleza | |
| Author | Almeida, Luciana Ramos | |
| Author | Guerra, Juliana Becattini | |
| Author | Rocha, Gifone Aguiar | |
| Author | Rocha, Andreia Maria Camargos | |
| Author | Melo, Fabrício Freire | |
| Author | Oliveira, Rodrigo Corrêa de | |
| Author | Bittencourt, Paulo | |
| Author | Carvalho, Simone Diniz | |
| Author | Queiroz, Dulciene Maria Magalhães | |
| Access date | 2022-07-01T17:27:07Z | |
| Available date | 2022-07-01T17:27:07Z | |
| Document date | 2008 | |
| Citation | MOURA, Sílvia Beleza et al. Toll-like receptor (TLR2, TLR4 and TLR5) gene polymorphisms and Helicobacter pylori infection in children with and without duodenal ulcer. Microbes and Infection, v. 10, n. 14–15, p. 1477-1483, 2008. doi.org/10.1016/j.micinf.2008.08.009 | pt_BR |
| ISSN | 1286-4579 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/53612 | |
| Sponsorship | CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO | pt_BR |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Toll-like receptor (TLR2, TLR4 and TLR5) gene polymorphisms and Helicobacter pylori infection in children with and without duodenal ulcer | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.micinf.2008.08.009 | |
| Abstract | Helicobacter pylori infection is mainly acquired in childhood, and polymorphisms in the host genes coding for Toll-like receptors (TLRs) may influence the innate and adaptive immune response to the infection, affecting the susceptibility to H. pylori or the disease outcomes. Our aim was to investigate whether TLR4, TLR2, and TLR5 polymorphisms were associated with H. pylori susceptibility and risk for duodenal ulcer in children. Gastric biopsy specimens were obtained at endoscopy for evaluation of H. pylori status, TLR4, TLR2 and TLR5 polymorphisms from 486 children (254 H. pylori-negative and 232 H. pyl-ori-positive: 72 with and 160 without duodenal ulcer). cagA status of H. pylori infection was investigated by PCR. The levels of gastric cytokines were detected by ELISA. H. pylori-positivity or duodenal ulcer were not associated with TLR2, TLR4 or TLR5 polymorphisms. Otherwise, the presence of TLR4 polymorphic allele was associated with infection by cagA-positive strains and with increased gastric levels of interleukin-8 and interleukin-10. TLR4 polymorphism might ultimately contribute to more severe consequences of the infection in adulthood since it was associated with susceptibility to cagA-positive H. pylori infection early in life. (C) 2008 Elsevier Masson SAS. All rights reserved | pt_BR |
| Affilliation | Universidade de Minas Gerais. Faculdade de Medicina. Laboratório de Pesquisas em Bacteriologia. Belo Horizonte, MG, Brazil/Universidade de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade de Minas Gerais. Faculdade de Medicina. Laboratório de Pesquisas em Bacteriologia. Belo Horizonte, MG, Brazil/Universidade de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade de Minas Gerais. Faculdade de Medicina. Laboratório de Pesquisas em Bacteriologia. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade de Minas Gerais. Faculdade de Medicina. Laboratório de Pesquisas em Bacteriologia. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade de Minas Gerais. Faculdade de Medicina. Laboratório de Pesquisas em Bacteriologia. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade de Minas Gerais. Faculdade de Medicina. Laboratório de Pesquisas em Bacteriologia. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Hospital das Clínicas. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Hospital das Clínicas. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade de Minas Gerais. Faculdade de Medicina. Laboratório de Pesquisas em Bacteriologia. Belo Horizonte, MG, Brazil | pt_BR |
| Subject | Helicobacter pylori | pt_BR |
| Subject | Gene polymorphism | pt_BR |
| Subject | Duodenal ulcer | pt_BR |
| Subject | Children | pt_BR |
