| Author | Paulino, Érica Tex | |
| Author | Lima, Monique Ribeiro de | |
| Author | Viçosa, Alessandra Lifsitch | |
| Author | Silva, Cleber Hooper da | |
| Author | Salomon, Claudio Javier | |
| Author | Real, Daniel Andrés | |
| Author | Leonardi, Dario | |
| Author | Silva, Clélia Christina Mello | |
| Author | Moraes Neto, Antonio Henrique Almeida de | |
| Access date | 2022-07-12T16:06:53Z | |
| Available date | 2022-07-12T16:06:53Z | |
| Document date | 2022 | |
| Citation | PAULINO, Érica Tex et al. The Effect of Different Formulations of Praziquantel in Reducing Worms in the Prepatent Period of Schistosomiasis in Murine Models. Frontiers in Public Health, v. 10, Article 848633, p. 1 - 10, May 2022. | pt_BR |
| ISSN | 2296-2565 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/53769 | |
| Language | eng | pt_BR |
| Publisher | Frontiers Media | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Esquistossomose | pt_BR |
| Subject in Portuguese | Praziquantel (PZQ) | pt_BR |
| Subject in Portuguese | Infecção pré-patente | pt_BR |
| Subject in Portuguese | Schistosoma mansoni (S. mansoni) | pt_BR |
| Subject in Portuguese | Nanoencapsulação | pt_BR |
| Title | The Effect of Different Formulations of Praziquantel in Reducing Worms in the Prepatent Period of Schistosomiasis in Murine Models | pt_BR |
| Type | Article | |
| DOI | 10.3389/fpubh.2022.848633 | |
| Abstract | Schistosomiasis is a widely distributed parasitic disease and one of the most important
neglected tropical diseases globally, for which Praziquantel® (PZQ) is the only available
treatment. In this context, tests with new PZQ formulations become relevant for disease
control. This study evaluated the effects of PZQ treatment in the prepatent phase
of schistosomiasis using two formulations: nanoencapsulated (PZQ-NANO) and active
pharmaceutical ingredient (PZQ-API). Five experimental groups were established, for
which the following serological parameters were evaluated: ALT, AST, ALP, and TP.
Animals treated with PZQ-API at 15 and 30 days post-infection showed decreased eggs
per gram of feces (EPG) compared to untreated infected animals. The same animals
showed reductions of 63.6 and 65.1%, respectively, at 60 days post-infection. Animals
treated with PZQ-NANO experienced no significant changes in EPG at any time of
observation. Animals treated with either PZQ-API or PZQ-NANO had higher ALT and AST
levels in the patent period (60 and 90 days post-infection). Treatment with PZQ, either
API or NANO, at 15 days post-infection reduced AST, ALT, and TP levels. It is concluded
that prepatent treatment with PZQ-API can reduce the parasite load of infected animals
and that treatment at 15 days post-infection can prevent increased serum levels of ALT,
AST, and TP. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Avaliação e Promoção da Saúde Ambiental. Rio de janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa de Medicina Tropical .Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Experimentação Animal. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Farmanguinhos. Laboratório de Experimentação Farmacotécnica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Ciência e Tecnologia em Biomodelos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade de Rosario. Faculdade de Ciências Bioquímicas e Farmacêuticas. Rosario, Argentina / Conselho Nacional de Pesquisas Científicas e Técnicas. Instituto de Química de Rosário. Rosario, Argentina. | pt_BR |
| Affilliation | Universidade de Rosario. Faculdade de Ciências Bioquímicas e Farmacêuticas. Rosario, Argentina / Conselho Nacional de Pesquisas Científicas e Técnicas. Instituto de Química de Rosário. Rosario, Argentina. | pt_BR |
| Affilliation | Universidade de Rosario. Faculdade de Ciências Bioquímicas e Farmacêuticas. Rosario, Argentina / Conselho Nacional de Pesquisas Científicas e Técnicas. Instituto de Química de Rosário. Rosario, Argentina. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Avaliação e Promoção da Saúde Ambiental. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Schistosomiasis | pt_BR |
| Subject | Praziquantel (PZQ), | pt_BR |
| Subject | Prepatent infection | pt_BR |
| Subject | Schistosoma mansoni (S. mansoni) | pt_BR |
| Subject | Nanoencapsulated | pt_BR |
