| Author | Oliveira, Rhaquel de Morais Alves Barbosa | |
| Author | Barreto, Francisca Kalline de Almeida | |
| Author | Pinto, Geovana Praça | |
| Author | Queiroz, Isabella Timbó | |
| Author | Araújo, Fernanda Montenegro de Carvalho | |
| Author | Lopes, Kilma Wanderley | |
| Author | Vale, Regina Lúcia Sousa do | |
| Author | Lemos, Daniele Rocha Queiroz | |
| Author | Cavalcante, John Washington | |
| Author | Siqueira, André Machado | |
| Author | Frutuoso, Lívia Carla Vinhal | |
| Author | Duarte, Elisabeth Carmen | |
| Author | Neto, Antônio Silva Lima | |
| Author | Freitas, André Ricardo Ribas | |
| Author | Cavalcanti, Luciano Pamplona de Góes | |
| Access date | 2022-07-13T23:56:45Z | |
| Available date | 2022-07-13T23:56:45Z | |
| Document date | 2022 | |
| Citation | OLIVEIRA, Rhaquel de Morais Alves Barbosa et al. Chikungunya Death Risk Factors in Brazil, in 2017: A case-control study. PloS one, v. 17, n. 4, p. 1-14, 2022. | pt_BR |
| ISSN | 1932-6203 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/53814 | |
| Language | eng | pt_BR |
| Publisher | Public Library of Science | pt_BR |
| Rights | open access | pt_BR |
| Title | Chikungunya Death Risk Factors in Brazil, in 2017: A case-control study | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1371/journal.pone.0260939 | |
| Abstract | Background: In 2016/2017 we had a major epidemic of chikungunya (CHIK) in Brazil, with many deaths. We evaluated to factors associated with deaths from CHIK that occurred in the city of Fortaleza, Brazil.
Methods: A matched case-control study was conducted (1:2), by sex, age (± 5 years) and neighborhood. Cases were CHIK deaths that occurred between January 1 and December 31, 2017, in Fortaleza, Brazil, and which were laboratory confirmed. Controls were laboratory confirmed CHIK patients occurring in the same neighborhood and in the same period, but which did not progress to death.
Results: 82 cases of CHIK and 164 controls were included. Considering the clinical history, significant associations were found between other chronic heart diseases (OR 3.8; CI: 1.53-9.26) and chronic kidney disease (OR 12.77; CI: 2.75-59.4). In the multivariate analysis of the variables related to signs and symptoms, fever (OR: 19.23 CI: 1.73-213.78), abdominal pain (OR: 3; 74 CI: 1.06-13.16), apathy (OR: 11.62 CI: 2.95-45.82) and dyspnea (OR: 50.61; CI: 12.37-207.18) were identified with greater likelihood of death from CHIK. It also stood out that altered blood glucose was associated with cases with a worse prognosis (OR: 13.5; CI: 1.3-135.0). Among the laboratory findings, only lymphocytes and albumin were not associated with greater likelihood of death.
Conclusion: The factors related with deaths were chronic kidney disease and previous heart disease, presence of fever, abdominal pain, apathy, dyspnea and arthritis and laboratory findings such as leukocytosis, leukopenia, thrombocytopenia, neutropenia and lymphopenia. | pt_BR |
| Affilliation | Universidade Federal do Ceará. Programa de Pós-graduação em Saúde Coletiva. Fortaleza, CE, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Ceará. Programa de Pós-graduação em Saúde Coletiva. Fortaleza, CE, Brasil. | pt_BR |
| Affilliation | Centro Universitário Christus. Faculdade de Medicina. Fortaleza, CE, Brasil. | pt_BR |
| Affilliation | Centro Universitário Christus. Faculdade de Medicina. Fortaleza, CE, Brasil. | pt_BR |
| Affilliation | Centro Universitário Christus. Faculdade de Medicina. Fortaleza, CE, Brasil / Laboratório Central de Saúde Pública do Ceará. Fortaleza, CE, Brasil. | pt_BR |
| Affilliation | Secretaria Municipal de Saúde de Fortaleza. Fortaleza, CE, Brasil. | pt_BR |
| Affilliation | Secretaria Municipal de Saúde de Fortaleza. Fortaleza, CE, Brasil. | pt_BR |
| Affilliation | Centro Universitário Christus. Faculdade de Medicina. Fortaleza, CE, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Ceará. Programa de Pós-graduação em Patologia. Fortaleza, CE, Brasil / Secretaria de Saúde do Estado do Ceará. Serviço de Verificação de Óbitos Dr Rocha Furtado. Fortaleza, CE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade de Brasília. Programa de Pós-Graduação em Medicina Tropical. Brasília, DF, Brasil / Ministério da Saúde. Secretaria de Vigilância em Saúde. Brasília, DF, Brasil. | pt_BR |
| Affilliation | Universidade de Brasília. Programa de Pós-Graduação em Medicina Tropical. Brasília, DF, Brasil. | pt_BR |
| Affilliation | Secretaria Municipal de Saúde de Fortaleza. Fortaleza, CE, Brasil. | pt_BR |
| Affilliation | Faculdade São Leopoldo Mandic de Campinas. Instituto de Pesquisa São Leopoldo Mandic. Campinas, SP, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Ceará. Programa de Pós-graduação em Saúde Coletiva. Fortaleza, CE, Brasil / Centro Universitário Christus. Faculdade de Medicina. Fortaleza, CE, Brasil / Universidade Federal do Ceará. Programa de Pós-graduação em Patologia. Fortaleza, CE, Brasil. | pt_BR |
| Subject | Chikungunya infection | pt_BR |
| Subject | Chikungunya virus | pt_BR |
| Subject | Brazil | pt_BR |
| Subject | Cardiovascular diseases | pt_BR |
| Subject | Fevers | pt_BR |
| Subject | Prognosis | pt_BR |
