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AutorFerrari, Teresa Cristina de Abreu
AutorGazzinelli, Giovanni
AutorOliveira, Rodrigo Corrêa
Fecha de acceso2022-07-26T18:53:21Z
Fecha de disponibilización2022-07-26T18:53:21Z
Fecha de publicación2008
ReferenciaFERRARI, Teresa Cristina de Abreu; GAZZINELLI, Giovanni; OLIVEIRA, Rodrigo Corrêa de. Immune response and pathogenesis of neuroschistosomiasis mansoni. Acta Trop., v. 108, n. 2-3, p. 83-88, 2008. doi: 10.1016/j.actatropica.2008.02.010.pt_BR
ISSN0001-706Xpt_BR
URIhttps://www.arca.fiocruz.br/handle/icict/53992
PromociónUNIVERSIDADE FEDERAL DE MINAS GERAISpt_BR
Idiomaengpt_BR
EditorElsevierpt_BR
Derechos de autorrestricted accesspt_BR
TítuloImmune response and pathogenesis of neuroschistosomiasis mansonipt_BR
Tipo del documentoArticle
DOI10.1016/j.actatropica.2008.02.010
Resumen en InglésThe involvement of the central nervous system (CNS) by schistosomes may or may not determine clinical manifestations. When symptomatic, neuroschistosomiasis (NS) is one of the most severe presentations of schistosome infection. Considering the symptomatic form, Schistosoma mansoni causes almost always spinal cord disease. Cerebral and spinal cord disorders in S. mansoni infections are inflammatory conditions of the CNS that cause mild-moderate impairment of the blood-brain barrier and intrathecal synthesis of antibodies against schistosomal antigens. Little is known about the pathogenesis of NS, but available evidence strongly suggests that it depends basically on the presence of parasite eggs in the nervous tissue and on the host's immune response against the trapped eggs. Numerous eggs surrounded by granulomas lodged together in circumscribed areas of the CNS damage the nervous tissue by both the mass effect and the egg-induced inflammatory reaction. Vasculitis of immune etiology, which causes isquemic lesions, may also play an important role in the genesis of the neurological symptoms. Although the mechanisms involved in the immunophatogenesis of NS are largely unknown, initial investigations on cerebrospinal fluid (CSF) and serum cytokine profiles suggest the occurrence of inflammation as well as a skewed Th2 immune response that probably occur both locally and systemically.pt_BR
AfiliaciónUniversidade Federal de Minas Gerais. Belo Horizonte, MG, Brasilpt_BR
AfiliaciónFundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Belo Horizonte, MG, Brasilpt_BR
AfiliaciónFundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Belo Horizonte, MG, Brasilpt_BR
Palavras clave en InglêsSchistosomiasispt_BR
Palavras clave en InglêsNeuroschistosomiasispt_BR
Palavras clave en InglêsSchistosoma mansonipt_BR
Palavras clave en InglêsCytokinespt_BR
Palavras clave en InglêsCerebrospinal fluidpt_BR
Palavras clave en InglêsBrazilpt_BR


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