| Author | Ratcliffe, Norman A. | |
| Author | Pacheco, João P. Furtado | |
| Author | Dyson, Paul | |
| Author | Castro, Helena Carla | |
| Author | Gonzalez, Marcelo S. | |
| Author | Azambuja, Patricia | |
| Author | Mello, Cícero B. | |
| Access date | 2022-07-30T15:31:39Z | |
| Available date | 2022-07-30T15:31:39Z | |
| Document date | 2022 | |
| Citation | RATCLIFFE, Norman A. et al. Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors. Parasites & Vectors, v. 15, n. 112, p. 1 - 31, 2022. | pt_BR |
| ISSN | 1756-3305 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/54085 | |
| Language | eng | pt_BR |
| Publisher | BMC | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Paratrangênese | pt_BR |
| Subject in Portuguese | Microbioma | pt_BR |
| Subject in Portuguese | Vetores de insetos | pt_BR |
| Subject in Portuguese | Mosquitos | pt_BR |
| Subject in Portuguese | Triatomíneos | pt_BR |
| Subject in Portuguese | Moscas tsé-tsé | pt_BR |
| Subject in Portuguese | Flebotomíneos | pt_BR |
| Subject in Portuguese | Segurança ambiental | pt_BR |
| Subject in Portuguese | Controle de pragas | pt_BR |
| Title | Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors | pt_BR |
| Type | Article | |
| DOI | 10.1186/s13071-021-05132-3 | |
| Abstract | This article presents an overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors.
It first briefly summarises some of the disease-causing pathogens vectored by insects and emphasises the need
for innovative control methods to counter the threat of resistance by both the vector insect to pesticides and the
pathogens to therapeutic drugs. Subsequently, the state of art of paratransgenesis is described, which is a particularly
ingenious method currently under development in many important vector insects that could provide an additional
powerful tool for use in integrated pest control programmes. The requirements and recent advances of the paratransgenesis
technique are detailed and an overview is given of the microorganisms selected for genetic modification,
the effector molecules to be expressed and the environmental spread of the transgenic bacteria into wild
insect populations. The results of experimental models of paratransgenesis developed with triatomines, mosquitoes,
sandflies and tsetse flies are analysed. Finally, the regulatory and safety rules to be satisfied for the successful environmental
release of the genetically engineered organisms produced in paratransgenesis are considered. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto de Biologia. Programa de Pós‑Graduação em Ciências e Biotecnologia. Niterói, RJ, Brasil / Department of Biosciences, Swansea University, Singleton Park, Swansea, UK | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto de Biologia. Programa de Pós‑Graduação em Ciências e Biotecnologia. Niterói, RJ, Brasil / Universidade Federal Fluminense. Instituto de Biologia. Laboratório de Biologia de Insetos. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Institute of Life Science, Medical School, Swansea University. Singleton Park, Swansea, UK. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto de Biologia. Programa de Pós‑Graduação em Ciências e Biotecnologia. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto de Biologia. Programa de Pós‑Graduação em Ciências e Biotecnologia. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto de Biologia. Programa de Pós‑Graduação em Ciências e Biotecnologia. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto de Biologia. Programa de Pós‑Graduação em Ciências e Biotecnologia. Niterói, RJ, Brasil. | pt_BR |
| Subject | Paratrangenesis | pt_BR |
| Subject | Microbiome | pt_BR |
| Subject | Insect vectors | pt_BR |
| Subject | Mosquitoes | pt_BR |
| Subject | Triatomines | pt_BR |
| Subject | Tsetse flies | pt_BR |
| Subject | Sandflies | pt_BR |
| Subject | Environmental safety | pt_BR |
| Subject | Pest control | pt_BR |
