| Author | Carvalho, Camila Rodrigues de | |
| Author | Vieira, Mariana de Lourdes Almeida | |
| Author | Cantrell, Charles L | |
| Author | Wedge, David E | |
| Author | Alves, Tânia Maria Almeida | |
| Author | Zani, Carlos Leomar | |
| Author | Pimenta, Raphael Sanzio | |
| Author | Sales Junior, Policarpo Ademar | |
| Author | Murta, Silvane Maria Fonseca | |
| Author | Romanha, Alvaro Jose | |
| Author | Rosa, Carlos Augusto | |
| Author | Rosa, Luiz Henrique | |
| Access date | 2022-08-01T13:15:06Z | |
| Available date | 2022-08-01T13:15:06Z | |
| Document date | 2016 | |
| Citation | CARVALHO, Camila Rodrigues de et al. Biological activities of ophiobolin K and 6-epi-ophiobolin K produced by the endophytic fungus Aspergillus calidoustus. Nat Prod Res., v. 30, n. 4, p. 478-481. doi: 10.1080/14786419.2015.1022777. | pt_BR |
| ISSN | 1478-6419 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/54094 | |
| Sponsorship | CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO | pt_BR |
| Language | eng | pt_BR |
| Publisher | Sciences | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Biological activities of ophiobolin K and 6-epi-ophiobolin K produced by the endophytic fungus Aspergillus calidoustus | pt_BR |
| Type | Article | |
| DOI | 10.1080/14786419.2015.1022777 | |
| Abstract | Endophytic fungi represent ubiquitous microbial organisms able to live in the tissues of different plants around the world and represent a prolific source of bioactive metabolites. In the present study, the endophytic fungus Aspergillus calidoustus was isolated from the medicinal plant Acanthospermum australe (Asteraceae), and identified using molecular, physiological and morphological methods. A methylene chloride crude extract of A. calidoustus has been produced and subjected to antifungal bioassay-directed fractionation which resulted in the isolation of the two bioactive compounds: ophiobolin K and 6-epi-ophiobolin K. These pure compounds displayed antifungal activity against fungal plant pathogens, protozoal activity against Trypanosoma cruzi, and cytotoxic activity against human tumoral cell lines. The results show that A. calidoustus was able to produce the antifungal and cytotoxic metabolites ophiobolin K and 6-epi-ophiobolin K, which may help the fungus to colonise and occupy the substratum as well as survive in natural environments. | pt_BR |
| Affilliation | Department of Microbiology. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | USDA-ARS. Natural Products Utilization Research Unit. Oxford , MS , USA. | pt_BR |
| Affilliation | USDA-ARS. Natural Products Utilization Research Unit. Oxford , MS , USA. | pt_BR |
| Affilliation | Laboratory of Chemistry of Natural Products. Rene Rachou Research Center. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Laboratory of Chemistry of Natural Products. Rene Rachou Research Center. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Laboratory of Environmental Microbiology. Federal University of Tocantins. Palmas, TO, Brazil. | pt_BR |
| Affilliation | Laboratory of Cellular and Molecular Parasitology. Rene Rachou Research Center. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Laboratory of Cellular and Molecular Parasitology. Rene Rachou Research Center. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Laboratory of Cellular and Molecular Parasitology. Rene Rachou Research Center. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Department of Microbiology. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Department of Microbiology. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil. | pt_BR |
| Subject | Chagas' disease | pt_BR |
| Subject | cancer | pt_BR |
| Subject | endophytic fungi | pt_BR |
| Subject | secondary metabolites | pt_BR |
