| Author | Silveira, Alexandre Barcelos Morais da | |
| Author | Freitas, Michelle Aparecida Ribeiro de | |
| Author | Oliveira, Elaine Cristina de | |
| Author | Gabriel Neto, Salustiano | |
| Author | Ostermayer, Alejandro Luquetti | |
| Author | Furness, John B. | |
| Author | Oliveira, Rodrigo Corrêa | |
| Author | Reis, Débora D'Avila | |
| Access date | 2022-08-01T19:02:17Z | |
| Available date | 2022-08-01T19:02:17Z | |
| Document date | 2008 | |
| Citation | SILVEIRA, Alexandre Barcelos Morais da et al. Neuronal plasticity of the enteric nervous system is correlated with chagasic megacolon development. Parasitology, v. 135, n. 11, p. 1337-1342, 2008. doi: 10.1017/S0031182008004770. | pt_BR |
| ISSN | 0031-1820 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/54184 | |
| Sponsorship | CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO | pt_BR |
| Language | eng | pt_BR |
| Publisher | Cambridge University Press | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Neuronal plasticity of the enteric nervous system is correlated with chagasic megacolon development | pt_BR |
| Type | Article | |
| DOI | 10.1017/S0031182008004770 | |
| Abstract | Chagas' disease is one of the few functional gastrointestinal disorders for which a causative agent has been identified. However, some pathological aspects of the chagasic megasyndromes are still incompletely understood. Chagasic megacolon is characterized by an inflammatory process, organ dilatation and neuronal reduction in both plexuses of the enteric nervous system (ENS). Although some studies on the ENS in Chagas' disease have been performed, the process of neuronal destruction and neuronal regeneration still remains unclear. Our hypothesis is that the regeneration process of the ENS may be involved with the mechanisms that prevent or retard organ dilatation and chagasic megacolon development. For that reason, we evaluated the neuronal regeneration with the marker GAP-43 in the colon's neuronal plexuses from chagasic patients with megacolon, and from non-infected individuals. Visual examination and quantitative analysis revealed an increased neuronal regeneration process in the dilated portion from chagasic patients when compared with the non-dilated portion and with non-infected individuals. We believe that this increased regeneration can be interpreted as an accentuated neuronal plasticity that may be a response of the ENS to avoid megacolon propagation to the entire organ and maintain the colon functional innervation | pt_BR |
| Affilliation | Research Center Rene ́ Rachou. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil, Brasil | pt_BR |
| Affilliation | Department of Parasitology. ICB. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil, Brasil | pt_BR |
| Affilliation | Department of Surgery, Medical School, Universidade Federal de Goias, GO, Brazil | pt_BR |
| Affilliation | Department of Surgery, Medical School, Universidade Federal de Goias, GO, Brazil | pt_BR |
| Affilliation | Chagas’ Disease Research Laboratory. IPTSP. Universidade Federal de Goias. GO, Brazil | pt_BR |
| Affilliation | Department of Anatomy & Cell Biology. University of Melbourne. Victoria, Australia | pt_BR |
| Affilliation | Research Center Rene ́ Rachou. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil, Brasil | pt_BR |
| Affilliation | Department of Morphology, ICB, Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil, Brasil | pt_BR |
| Subject | Chagas' disease | pt_BR |
| Subject | chagasic megacolon | pt_BR |
| Subject | enteric nervous system | pt_BR |
| Subject | neuronal regeneration | pt_BR |
| Subject | GAP-43 | pt_BR |
