| Autor | Morgado, Mariza Gonçalves | |
| Autor | Sabino, Ester C. | |
| Autor | Shpaer, Eugene G. | |
| Autor | Bongertz, Vera | |
| Autor | Brigido, Luis F. | |
| Autor | Guimaraes, Mark Drew Crosland | |
| Autor | Castilho, Euclides Ayres de | |
| Autor | Castro Filho, Bernardo Galvão | |
| Autor | Mullins, James I. | |
| Autor | Hendry, R. Michael | |
| Autor | Mayer, Allen | |
| Data de acesso | 2010-08-23T16:58:21Z | pt_BR |
| Data de acesso | 2010-11-04T14:19:42Z | |
| Data de disponibilização | 2010-08-23T16:58:21Z | pt_BR |
| Data de disponibilização | 2010-11-04T14:19:42Z | |
| Data do publicação | 1994 | |
| Citação | MORGADO, Mariza G. et al. V3 region polymorphisms in HIV-1 from Brazil: prevalence of subtype B strains divergent from North American/European prototype and detection of subtype F. AIDS Research and Human Retroviruses, v. 10, n. 5, p. 569-576, 1994. | pt_BR |
| ISSN | 0889-2229 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/541 | |
| Fomento | This work was partially supported by Grants ROI-HL-48367 and ROI-AI-32885 (NIH), by the NAID/PAHO/Brazilian Ministry of Health, and by the AIDS Programa da FIOCRUZ Brazilian
Ministry of Health.
1. | pt_BR |
| Idioma | eng | pt_BR |
| Editor | Mary Ann Liebert, Inc., Publishers | pt_BR |
| Direito Autoral | open access | |
| Título | V3 region polymorphisms in HIV-1 from Brazil: prevalence of subtype B strains divergent from North American/European prototype and detection of subtype F | pt_BR |
| Tipo do documento | Article | |
| DOI | 10.1089/aid.1994.10.569 | pt_BR |
| Resumo em Inglês | Viral DNA sequences were determined over the V3 region of env from 28 infected individuals living in the high mV·l prevalence Brazilian cities of Rio de Janeiro and São Paulo. Twenty-six belonged to envelope sequence subtype B, prevalent in North America and Europe, and one was c1assifiedas subtype F, found recently in Brazil and in Romania (one appeared to be a B/F recombinant). Octameric sequences at the tip of the subtype B V3 loops were variable and distinct from those prevalent in North America and Europe. The GPGR motü, prevalent in North AmericanlEuropean strains, was found in only 8 (28.5%) sequences, whereas GWGR was found in 12 (43%) and novel sequences in 8 (28.5%). Brazilian subtype B sequences also diverged from the consensus North AmericanlEuropean strains over the remainder of the V3loop. These results suggest that Brazilian mv·l B strains may have important antigenic differences from prototype subtype B strains currently being evaluated for use in HIV vaccines. These results should be taken into account for future vaccine programs in Brazil. | pt_BR |
| Afiliação | Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Department of Immunology. Rio de Janeiro, RJ, Brazil. | |
| Afiliação | Instituto Adolfo Lutz. São Paulo, SP, Brazil. | |
| Afiliação | Stanford University. School of Medicine. Department of Microbiology and Immunology. Stanford, CA, USA. | |
| Afiliação | Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Department of Immunology. Rio de Janeiro, RJ, Brazil. | |
| Afiliação | Instituto Adolfo Lutz. São Paulo, SP, Brazil. | |
| Afiliação | Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Rio de Janeiro, RJ, Brazil. | |
| Afiliação | Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Rio de Janeiro, RJ, Brazil. | |
| Afiliação | Oswaldo Cruz Foundation. Gonçalo Muniz Institute. Salvador, BA, Brazil. | |
| Afiliação | Yiral and Rickettsial Disease Laboratory, California Department of Health Services. Berkeley, California | |
| Palavras-chave em inglês | DNA, Viral | |
| Palavras-chave em inglês | AIDS Vaccines | |
| Palavras-chave em inglês | Vaccines | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
