| Author | Johann, Susana | |
| Author | Silva, Daniele L. | |
| Author | Martins, Cleide Viviane Buzanello | |
| Author | Zani, Carlos Leomar | |
| Author | Pizzolatti, Moacir Geraldo | |
| Author | Stoianoff, Maria Aparecida de Resende | |
| Access date | 2022-08-10T12:45:50Z | |
| Available date | 2022-08-10T12:45:50Z | |
| Document date | 2008 | |
| Citation | JOHANN, Susana et al. Inhibitory effect of extracts from Brazilian medicinal plants on the adhesion of Candida albicans to buccal epithelial cells. World J Microbiol Biotechnol., v 24, p. 2459–2464, 2008. doi.org/10.1007/s11274-008-9768-5 | pt_BR |
| ISSN | 1573-0972 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/54549 | |
| Language | eng | pt_BR |
| Publisher | Springer | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Inhibitory effect of extracts from Brazilian medicinal plants on the adhesion of Candida albicans to buccal epithelial cells | pt_BR |
| Type | Article | |
| DOI | 10.1007/s11274-008-9768-5 | |
| Abstract | Plants are known to produce a plethora of secondary metabolites which are recognized as a useful source of new drugs or drug leads. Extracts and fractions of Schinus terebinthifolius Raddi (Anacardiaceae), Piper regnellii C.D.C. (Piperaceae), Rumex acetosa L. (Polygonaceae), and Punica granatum L. (Punicaceae) were assessed for their antifungal activity against eight clinical isolates of C. albicans. They were also evaluated for their effect on the adhesion of these C. albicans isolates to buccal epithelial cells (BECs). The ethyl acetate fraction from the leaves of S. terebinthifolius showed promising activity, inhibiting the growth of three C. albicans isolates at 7.8 mu g ml(-1) and significantly inhibiting their adhesion to BEC at 15 mu g ml(-1). In addition, this fraction did not show cytotoxic activity against murine macrophages. The results show the potential of the plant extracts studied as a source of new antifungal compounds. Further studies are necessary for isolation and characterization of the active compounds of these plants | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Microbiologia. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Laboratorio de Quımica de Produtos Naturais. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Microbiologia. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Estadual do Oeste do Parana. Centro de Engenharias e Ciencias Exatas. Toledo, PR, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Laboratorio de Quımica de Produtos Naturais. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Universidade Federal de Santa Catarina. Departamento de Quımica. Florianopolis, SC, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Microbiologia. Belo Horizonte, MG, Brazil | pt_BR |
| Subject | anti-adhesion | pt_BR |
| Subject | antifungal | pt_BR |
| Subject | buccal epithelial cells | pt_BR |
| Subject | cytotoxic activity | pt_BR |
| Subject | Punica granatum | pt_BR |
| Subject | Schinus terebinthifolius | pt_BR |
