| Author | Oliveira, Jéssica Araujo da Paixão de | |
| Author | Athaide, Mariana Martins de | |
| Author | Rahman, Atta Ur | |
| Author | Barbosa, Mayara Garcia de Mattos | |
| Author | Jardim, Marcia Maria | |
| Author | Moraes, Milton Ozório | |
| Author | Pinheiro, Roberta Olmo | |
| Access date | 2022-08-11T14:17:11Z | |
| Available date | 2022-08-11T14:17:11Z | |
| Document date | 2022 | |
| Citation | OLIVEIRA, Jéssica Araujo da Paixão de et al. Kynurenines in the pathogenesis of peripheral neuropathy during leprosy and COVID-19. Frontiers in Cellular and Infection Microbiology, v. 12, p. 1-16, 23 Feb. 2022. | |
| ISSN | 2235-2988 | |
| URI | https://www.arca.fiocruz.br/handle/icict/54594 | |
| Description | Produção científica do Laboratório de Hanseníase. | pt_BR |
| Language | eng | en_US |
| Publisher | Frontiers Media | |
| Rights | open access | |
| Title | Kynurenines in the pathogenesis of peripheral neuropathy during leprosy and COVID-19 | en_US |
| Type | Article | |
| DOI | 10.3389/fcimb.2022.815738 | |
| Abstract | Inflammatory disorders are associated with the activation of tryptophan (TRYP) catabolism via the kynurenine pathway (KP). Several reports have demonstrated the role of KP in the immunopathophysiology of both leprosy and coronavirus disease 19 (COVID-19). The nervous system can be affected in infections caused by both Mycobacterium leprae and SARS-CoV-2, but the mechanisms involved in the peripheral neural damage induced by these infectious agents are not fully understood. In recent years KP has received greater attention due the importance of kynurenine metabolites in infectious diseases, immune dysfunction and nervous system disorders. In this review, we discuss how modulation of the KP may aid in controlling the damage to peripheral nerves and the effects of KP activation on neural damage during leprosy or COVID-19 individually and we speculate its role during co-infection. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | University of Michigan. Department of Surgery. Ann Arbor, MI, USA. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro. Centro Biomédico. Hospital Universitário Pedro Ernesto. Departamento de Neurologia. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | |
| Subject | Kynurenine pathway | en_US |
| Subject | Peripheral neuropathy | en_US |
| Subject | Leprosy | en_US |
| Subject | COVID-19 | en_US |
| Subject | Tryptophan | en_US |
| e-ISSN | 2235-2988 | |
