| Author | Souza, Thiara Manuele Alves de | |
| Author | Santos, Caroline Fernandes | |
| Author | Oliveira, Jéssica Araújo da Paixão de | |
| Author | Tomé, Larissa Cristina Teixeira | |
| Author | Fiestas-Solórzano, Victor Edgar | |
| Author | Nunes, Priscila Conrado Guerra | |
| Author | Guimarães, Gabriel Macedo Costa | |
| Author | Sánchez-Arcila, Juan Camilo | |
| Author | Paiva, Iury Amâncio | |
| Author | Souza, Luís Jose de | |
| Author | Damasco, Paulo Vieira | |
| Author | Frutuoso, Válber da Silva | |
| Author | Heringer, Manoela | |
| Author | Pinto, Luzia Maria de Oliveira | |
| Author | Pinheiro, Roberta Olmo | |
| Author | Santos, Flavia Barreto dos | |
| Author | Azevedo, Elzinandes Leal de | |
| Access date | 2022-08-14T17:21:34Z | |
| Available date | 2022-08-14T17:21:34Z | |
| Document date | 2022 | |
| Citation | SOUZA, Thiara Manuele Alves de et al. Increased Indoleamine 2,3-Dioxygenase 1 (IDO-1) Activity and Inflammatory Responses during Chikungunya Virus Infection. Pathogens, v. 11, 444, p. 1 - 21, Apr. 2022. | pt_BR |
| ISSN | 2076-0817 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/54631 | |
| Language | eng | pt_BR |
| Publisher | MDPI | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Chikungunya | pt_BR |
| Subject in Portuguese | Indoleamina 2,3-dioxigenase 1 | pt_BR |
| Subject in Portuguese | Citocinas | pt_BR |
| Subject in Portuguese | Quimiocinas | pt_BR |
| Title | Increased Indoleamine 2,3-Dioxygenase 1 (IDO-1) Activity and Inflammatory Responses during Chikungunya Virus Infection | pt_BR |
| Type | Article | |
| DOI | 10.3390/pathogens11040444 | |
| Abstract | Chikungunya virus (CHIKV) infection causes intense cytokine/chemokine inflammatory
responses and debilitating joint pain. Indoleamine2,3–dioxygenase 1 (IDO-1) is an enzyme that
initiates the tryptophan degradation that is important in initial host innate immune defense against
infectious pathogens. Besides that, IDO-1 activation acts as a regulatory mechanism to prevent overactive
host immune responses. In this study, we evaluated IDO-1 activity and cytokine/chemokine
patterns in CHIKV patients. Higher IDO-1 (Kyn/Trp ratio) activation was observed during the
early acute phase of CHIKV infection and declined in the chronic phase. Importantly, increased
concentrations of Tumor Necrosis Factor- (TNF- ), Interleukin-6 (IL-6), Interferon
(IFN-
), C-C
motif chemokine ligand 2/Monocyte Chemoattractant Protein-1 (CCL2/MCP-1) and C-X-C motif
chemokine ligand 10/Interferon Protein-10 (CXCL10/IP-10) were found in the acute phase of infection,
while C-C motif chemokine ligand 4/Macrophage Inflammatory Protein 1 (CCL4/MIP-1 )
was found at increased concentrations in the chronic phase. Likewise, CHIKV patients with arthritis
had significantly higher concentrations of CCL4/MIP-1 compared to patients without arthritis.
Taken together, these data demonstrated increased IDO-1 activity, possibly exerting both antiviral
effects and regulating exacerbated inflammatory responses. CCL4/MIP-1 may have an important
role in the persistent inflammation and arthritic symptoms following chikungunya infection. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, GB, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, GB, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Faculdade de Medicina. Centro de Referência em Doenças Imunológicas e Infecciosas. Campos dos Goytacazes, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffrée Guinle. Escola de Medicina e Cirurgia. Departamento de Medicina Geral. Rio de Janeiro, RJ, Brasil. Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Estadual do Cérebro Paulo Niemeyer. Laboratório de Biomedicina Cerebral. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, GB, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, GB, Brasil. | pt_BR |
| Subject | Chikungunya | pt_BR |
| Subject | Indoleamine 2,3-dioxygenase 1 | pt_BR |
| Subject | Cytokines | pt_BR |
| Subject | Chemokines | pt_BR |
