| Author | Lima, Maiara N. | |
| Author | Silva, Maria C. Barbosa | |
| Author | Maron-Gutierrez, Tatiana | |
| Access date | 2022-08-17T11:09:33Z | |
| Available date | 2022-08-17T11:09:33Z | |
| Document date | 2022 | |
| Citation | LIMA, Maiara N.; SILVA, Maria C. Barbosa; MARON-GUTIERREZ, Tatiana. Microglial Priming in Infections and Its Risk to Neurodegenerative Diseases. Frontiers in Cellular Neuroscience. v. 16, Article 878987, p. 1 - 13, June 2022. | pt_BR |
| ISSN | 1662-5102 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/54674 | |
| Language | eng | pt_BR |
| Publisher | Frontiers Media | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Microglia pró-inflamatória | pt_BR |
| Subject in Portuguese | Primário microglial | pt_BR |
| Subject in Portuguese | Doenças infecciosas | pt_BR |
| Subject in Portuguese | Doenças neurodegenerativas | pt_BR |
| Subject in Portuguese | Envelhecimento | pt_BR |
| Subject in Portuguese | Inflamação do sistema nervoso central | pt_BR |
| Subject in Portuguese | Inflamação cerebral | pt_BR |
| Title | Microglial Priming in Infections and Its Risk to Neurodegenerative Diseases | pt_BR |
| Type | Article | |
| DOI | 10.3389/fncel.2022.878987 | |
| Abstract | Infectious diseases of different etiologies have been associated with acute and long-term
neurological consequences. The primary cause of these consequences appears to be
an inflammatory process characterized primarily by a pro-inflammatory microglial state.
Microglial cells, the local effectors’ cells of innate immunity, once faced by a stimulus, alter
their morphology, and become a primary source of inflammatory cytokines that increase
the inflammatory process of the brain. This inflammatory scenario exerts a critical role in
the pathogenesis of neurodegenerative diseases. In recent years, several studies have
shown the involvement of the microglial inflammatory response caused by infections
in the development of neurodegenerative diseases. This has been associated with a
transitory microglial state subsequent to an inflammatory response, known as microglial
priming, in which these cells are more responsive to stimuli. Thus, systemic inflammation
and infections induce a transitory state in microglia that may lead to changes in their
state and function, making priming them for subsequent immune challenges. However,
considering that microglia are long-lived cells and are repeatedly exposed to infections
during a lifetime, microglial priming may not be beneficial. In this review, we discuss the
relationship between infections and neurodegenerative diseases and how this may rely
on microglial priming. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Pro-inflammatory microglia | pt_BR |
| Subject | Microglial priming | pt_BR |
| Subject | Infectious diseases | pt_BR |
| Subject | Neurodegenerative diseases | pt_BR |
| Subject | Aging | pt_BR |
| Subject | Central nervous system inflammation | pt_BR |
| Subject | Brain inflammation | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
