| Author | Ferreira, Rayssa Vieira Brandão | |
| Author | Pinheiro, Hannah Cavalcante Guedes | |
| Author | Melo, Fabiana de Oliveira | |
| Author | Gama, Gabriela Lopes | |
| Author | Monteiro, Lucia Maria Costa | |
| Author | Fontes, Juliana Marin | |
| Author | Cruz, Glaura Nisya de Oliveira | |
| Author | Araújo, Grace Ferreira de | |
| Author | Amorim, Melania Maria Ramos | |
| Author | Melo, Adriana | |
| Access date | 2022-08-17T16:40:02Z | |
| Available date | 2022-08-17T16:40:02Z | |
| Document date | 2022 | |
| Citation | FERREIRA, Rayssa Vieira Brandão et al. Urological outcomes in children with congenital Zika syndrome: the experience of a cohort in Campina Grande, Brazil. Tropical Medicine and International Health, v. 27, n. 6, p. 583-591, 2022. | pt_BR |
| ISSN | 1360-2276 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/54682 | |
| Sponsorship | Ministry of Science, Technology, Innovations and Communications, the Ministry of Education and the Ministry of Health through the MCTIC/FNDCT-CNPq/MEC-CAPES/MS-Decit grant Program for the Prevention and Combat of Zika virus (grants 440488/2016-8, 428837/2016-6, 443372/2016-0,
425136/2016-7, 440580/2016-1, and 442611/2019-6) | pt_BR |
| Language | eng | pt_BR |
| Publisher | Wiley | pt_BR |
| Rights | restricted access | |
| Title | Urological outcomes in children with congenital Zika syndrome: the experience of a cohort in Campina Grande, Brazil | en_US |
| Type | Article | |
| DOI | 10.1111/tmi.13754 | |
| Abstract | Objective: To describe the urological outcomes in children with congenital Zika syndrome (CZS) and investigate the relationship between clinical and urological findings in this population. Methods: This cross-sectional study involved children with CZS followed up by a referral centre for children with microcephaly in the state of Paraiba in northeast Brazil. The urological evaluation included clinical history, urine culture results, ultrasonography of the urinary tract, and urodynamic evaluation, following the protocol proposed by Costa Monteiro et al. (2017). Descriptive statistical analysis was performed in addition to association and correlation tests, considering clinical and urodynamic variables. Results: Among the 88 children with CZS (35.5 5.5 months), 97.7% had microcephaly, and 51% presented urinary tract infection (UTI) confirmed with clinical history and lab tests. The number of confirmed UTI episodes varied from one to 14 per child. The urodynamic evaluation confirmed the presence of an overactive bladder in 78 children and incomplete voiding in 50. Urodynamic findings were associated with the number of confirmed UTI episodes, child’s sex, and actual weight, in addition to the use of anticonvulsant and myorelaxant drugs. Conclusions: UTIs were confirmed in most children. Other urological outcomes observed were overactive bladder and low bladder capacity, which were associated with the number of confirmed UTI episodes, use of anticonvulsants and myorelaxants, and the child’s sex and weight. These are treatable conditions, and it is paramount that paediatricians, neonatologists, and infectious disease specialists are aware of them to make clinical decisions and help reduce the risk of renal damage and other morbidities. | en_US |
| Affilliation | Instituto de Pesquisa Professor Joaquim Amorim Neto. Campina Grande, PB, Brasil. | pt_BR |
| Affilliation | Instituto de Pesquisa Professor Joaquim Amorim Neto. Campina Grande, PB, Brasil. | pt_BR |
| Affilliation | Instituto de Pesquisa Professor Joaquim Amorim Neto. Campina Grande, PB, Brasil. | pt_BR |
| Affilliation | Instituto de Pesquisa Professor Joaquim Amorim Neto. Campina Grande, PB, Brasil / Centro Universitário Facisa. Campina Grande, PB, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto de Pesquisa Professor Joaquim Amorim Neto. Campina Grande, PB, Brasil. | pt_BR |
| Affilliation | Instituto de Pesquisa Professor Joaquim Amorim Neto. Campina Grande, PB, Brasil / Centro Universitário Facisa. Campina Grande, PB, Brasil. | pt_BR |
| Subject | Congenital abnormalities | pt_BR |
| Subject | Congenital Zika syndrome | pt_BR |
| Subject | Microcephaly | pt_BR |
| Subject | Neurogenic bladder | pt_BR |
| Subject | Neurological lower urinary tract dysfunction | pt_BR |
| e-ISSN | 1365-3156 | |
