| Author | Hamanaka, Tatiana | |
| Author | Ribeiro, Carla Trevisan Martins | |
| Author | Pone, Sheila | |
| Author | Gomes Junior, Saint Clair | |
| Author | Nielsen-Saines, Karin | |
| Author | Brickley, Elizabeth B. | |
| Author | Moreira, Maria Elisabeth | |
| Author | Pone, Marcos | |
| Access date | 2022-08-18T14:33:58Z | |
| Available date | 2022-08-18T14:33:58Z | |
| Document date | 2022 | |
| Citation | HAMANAKA, Tatiana et al. Longitudinal follow-up of gross motor function in children with congenital Zika virus syndrome from a cohort in Rio de Janeiro, Brazil. Viruses, v. 14, n. 6, p. 1-9, 28 May 2022. | pt_BR |
| ISSN | 1999-4915 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/54710 | |
| Sponsorship | RO1/ AI140718/AI/NIAID NIH HHS/United States | pt_BR |
| Sponsorship | R01 AI140718/AI/NIAID NIH HHS/United States | pt_BR |
| Sponsorship | WT_/Wellcome Trust/United Kingdom | pt_BR |
| Sponsorship | 205377/Z/16/Z/WT_/Wellcome Trust/United Kingdom | pt_BR |
| Language | eng | pt_BR |
| Publisher | MDPI | pt_BR |
| Rights | open access | |
| MeSH | Adolescent | pt_BR |
| MeSH | Brazil / epidemiology | pt_BR |
| MeSH | Child | pt_BR |
| MeSH | Cohort Studies | pt_BR |
| MeSH | DNA Viruses | pt_BR |
| MeSH | Follow-Up Studies | pt_BR |
| MeSH | Humans | pt_BR |
| MeSH | Infant | pt_BR |
| MeSH | Prospective Studies | pt_BR |
| MeSH | Viruses, Unclassified | pt_BR |
| MeSH | Zika Virus Infection / congenital | pt_BR |
| MeSH | Zika Virus | pt_BR |
| Title | Longitudinal follow-up of gross motor function in children with congenital Zika virus syndrome from a cohort in Rio de Janeiro, Brazil | en_US |
| Type | Article | pt_BR |
| DOI | 10.3390/v14061173 | |
| Abstract | Knowledge of how congenital Zika syndrome (CZS) impacts motor development of children longitudinally is important to guide management. The objective of the present study was to describe the evolution of gross motor function in children with CZS in a Rio de Janeiro hospital. In children with CZS without arthrogryposis or other congenital osteoarticular malformations who were followed in a prospective cohort study, motor performance was evaluated at two timepoints using the Gross Motor Function Classification System (GMFCS) and the Gross Motor Function Measurement test (GMFM-88). Among 74 children, at the baseline evaluation, the median age was 13 (8-24) months, and on follow-up, 28 (24-48) months. According to GMFCS at the second timepoint, 6 children were classified as mild, 11 as moderate, and 57 as severe. In the GMFM-88 assessment, children in the severe group had a median score of 10.05 in the baseline evaluation and a follow-up score of 12.40, the moderate group had median scores of 25.60 and 29.60, and the mild group had median scores of 82.60 and 91.00, respectively. Although a small developmental improvement was observed, the motor impairment of children was mainly consistent with severe cerebral palsy. Baseline motor function assessments were predictive of prognosis. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | University of California. David Geffen School of Medicine. Los Angeles, CA, USA. | pt_BR |
| Affilliation | London School of Hygiene & Tropical Medicine. London, UK. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Zika virus | en_US |
| Subject | Congenital zika virus syndrome | en_US |
| Subject | Motor development | en_US |
| e-ISSN | 1999-4915 | pt_BR |
