| Author | Flores, Geane Lopes | |
| Author | Mota, Jurema Corrêa | |
| Author | Andrade, Larissa Tropiano da Silva | |
| Author | Lopes, Renata Serrano | |
| Author | Bastos, Francisco Inácio Pinkusfeld Monteiro | |
| Author | Villar, Livia Melo | |
| Access date | 2022-08-18T14:40:31Z | |
| Available date | 2022-08-18T14:40:31Z | |
| Document date | 2022 | |
| Citation | FLORES, Geane Lopes et al. Performance of HCV Antigen Testing for the Diagnosis and Monitoring of Antiviral Treatment: A Systematic Review and Meta-Analysis. BioMed Research International, v. 2022, Article ID 734855, p. 1 - 17, 2022. | pt_BR |
| ISSN | 2314-6141 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/54711 | |
| Language | eng | pt_BR |
| Publisher | Hindawi | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Desempenho | pt_BR |
| Subject in Portuguese | Teste do antígeno do HCV | pt_BR |
| Subject in Portuguese | Diagnóstico | pt_BR |
| Subject in Portuguese | Monitoramento do | pt_BR |
| Subject in Portuguese | Tratamento antiviral | pt_BR |
| Subject in Portuguese | Revisão sistemática e Meta-análise | pt_BR |
| Title | Performance of HCV Antigen Testing for the Diagnosis and Monitoring of Antiviral Treatment: A Systematic Review and Meta-Analysis | pt_BR |
| Type | Article | |
| DOI | 10.1155/2022/7348755 | |
| Abstract | Background and Aims. Active hepatitis C virus (HCV) infection is based on the detection of HCV RNA that it is effective but
presents high cost and the need to hire trained personnel. This systematic review and meta-analysis is aimed at evaluating the
diagnostic accuracy of HCV Ag testing to identify HCV cases and to monitor antiviral treatment including DAA treatment.
Methods. The studies were identified through a search in PubMed, Lilacs, and Scopus from 1990 through March 31, 2020.
Cohort, cross-sectional, and randomized controlled trials were included. Two independent reviewers extracted data and
assessed quality using an adapted Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool. Our primary
outcome was to determine the accuracy of HCV Ag detection for the diagnosis, which we estimated using random-effects
meta-analysis. Results. Of 3,062 articles identified, 54 met our eligibility criteria. The studies described cohorts from 20
countries, including 14,286 individuals with chronic HCV individuals. Studies for ECLIA technology demonstrated highest
quality compared to studies that used ELISA. The pooled sensitivity and specificity (95% CI) for HCV Ag detection of active
HCV infection were 98.82% (95%CI = 98:04%; 99.30%) and 98.95% (95%CI = 97:84%; 99.49%), respectively. High concordance
was found between HCV Ag testing and HCV RNA detection 89.7% and 95% to evaluate antiviral treatment. Conclusions.
According to our findings, HCV Ag testing could be useful to identify HCV active cases in low-resource areas. For antiviral
treatment, HCV Ag testing will be useful at the end of treatment. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Comunicação e Informação em Ciência e Tecnologia em Saúde. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Comunicação e Informação em Ciência e Tecnologia em Saúde. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Performance | pt_BR |
| Subject | HCV Antigen Testing | pt_BR |
| Subject | Diagnosis | pt_BR |
| Subject | Monitoring | pt_BR |
| Subject | Antiviral Treatment | pt_BR |
| Subject | Systematic Reviewand Meta-Analysis | pt_BR |
