Author | Bitencourt, Tamires A. | |
Author | Pessoni, André M. | |
Author | Oliveira, Bianca T. M. | |
Author | Alves, Lysangela Ronalte | |
Author | Almeida, Fausto | |
Access date | 2022-09-21T17:18:49Z | |
Available date | 2022-09-21T17:18:49Z | |
Document date | 2022 | |
Citation | BITENCOURT, Tamires A. et al. The RNA content of fungal extracellular vesicles: at the “cutting-edge” of pathophysiology regulation. Cells, v. 11, n. 2184, p. 1–11, 2022. | en_US |
ISSN | 2073-4409 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/54831 | |
Language | por | en_US |
Publisher | MDPI | en_US |
Rights | open access | en_US |
Subject in Portuguese | Micoses | en_US |
Subject in Portuguese | RNA | en_US |
Subject in Portuguese | Vias de Sinalização | en_US |
Title | The RNA content of fungal extracellular vesicles: at the “cutting-edge” of pathophysiology regulation | en_US |
Type | Article | en_US |
DOI | 10.3390/ cells11142184 | |
Abstract | The role of extracellular vesicles (EVs) in interkingdom communication is widely accepted, and their role in intraspecies communication has been strengthened by recent research. Based on the regulation promoted by EV-associated molecules, the interactions between host and pathogens can reveal different pathways that ultimately affect infection outcomes. As a great part of the regulation is ascribable to RNA contained in EVs, many studies have focused on profiling RNAs in fungal and host EVs, tracking their accumulation during infection, and identifying potential target genes. Herein, we overview the main classes of RNA contained in fungal EVs and the biological processes regulated by these molecules, portraying a state-of-the-art picture of RNAs loaded in fungal EVs, while also raising several questions to drive future investigations. Our compiled data show unambiguously that EVs act as key elements in signaling pathways, and play a crucial role in pathosystems. A complete understanding of the processes that govern RNA content loading and trafficking, and its effect on recipient cells, will lead to improved technologies to ward off infectious agents that threaten human health. | en_US |
Affilliation | Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Bioquímica e Imunologia. Ribeirão Preto, SP, Brasil. | en_US |
Affilliation | Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Bioquímica e Imunologia. Ribeirão Preto, SP, Brasil. | en_US |
Affilliation | Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Bioquímica e Imunologia. Ribeirão Preto, SP, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Regulação da Expressão Gênica. Curitiba, PR, Brasil. | en_US |
Affilliation | Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Bioquímica e Imunologia. Ribeirão Preto, SP, Brasil. | en_US |
Subject | Mycoses | en_US |
Subject | Signal Transduction | en_US |
Subject | Extracellular Vesicles | en_US |
Subject in Spanish | Micosis | en_US |
Subject in Spanish | ARN | en_US |
Subject in Spanish | Transducción de Señal | en_US |
Subject in Spanish | Vesículas Extracelulares | en_US |
Subject in French | Vésicules extracellulaires | en_US |
DeCS | Infecções Fúngicas | en_US |
DeCS | Ácido Ribonucleico | en_US |
DeCS | Transdução de Sinais | en_US |
DeCS | Vesículas Extracelulares | en_US |