Author | Araujo, José Deney | |
Author | Silva, Juan Carlo Santos E | |
Author | Martins, André Guilherme Costa | |
Author | Sampaio, Vanderson | |
Author | Castro, Daniel Barros de | |
Author | Souza, Robson F de | |
Author | Giddaluru, Jeevan | |
Author | Ramos, Pablo Ivan P | |
Author | Pita, Robespierre | |
Author | Barreto, Mauricio L | |
Author | Barral Netto, Manoel | |
Author | Nakaya, Helder I | |
Access date | 2022-09-23T12:44:57Z | |
Available date | 2022-09-23T12:44:57Z | |
Document date | 2022 | |
Citation | ARAUJO, José Deney et al. Tucuxi-blast: enabling fast and accurate record linkage of large-scale health-related administrative databases through a DNA-encoded approach. PeerJ . p. 1-17, 2022. | en_US |
ISSN | 2167-8359 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/54852 | |
Sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP).
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). | en_US |
Language | eng | en_US |
Publisher | PeerJ | en_US |
Rights | open access | en_US |
MeSH | Epidemiology | en_US |
Subject in Portuguese | Codificado NA | en_US |
Subject in Portuguese | Ligação de registro | en_US |
Subject in Portuguese | Ferramentas genômicas | en_US |
Subject in Portuguese | Epidemiologia | en_US |
Subject in Portuguese | Explosão | en_US |
Title | Tucuxi-blast: enabling fast and accurate record linkage of large-scale health-related administrative databases through a DNA-encoded approach | en_US |
Type | Article | en_US |
DOI | 10.7717/peerj.13507 | |
Abstract | Background: Public health research frequently requires the integration of information from different data sources. However, errors in the records and the high computational costs involved make linking large administrative databases using record linkage (RL) methodologies a major challenge. Methods: We present Tucuxi-BLAST, a versatile tool for probabilistic RL that utilizes a DNA-encoded approach to encrypt, analyze and link massive administrative databases. Tucuxi-BLAST encodes the identification records into DNA. BLASTn algorithm is then used to align the sequences between databases. We tested and benchmarked on a simulated database containing records for 300 million individuals and also on four large administrative databases containing real data on Brazilian patients. Results: Our method was able to overcome misspellings and typographical errors in administrative databases. In processing the RL of the largest simulated dataset (200k records), the state-of-the-art method took 5 days and 7 h to perform the RL, while Tucuxi-BLAST only took 23 h. When compared with five existing RL tools applied to a gold-standard dataset from real health-related databases, Tucuxi-BLAST had the highest accuracy and speed. By repurposing genomic tools, Tucuxi-BLAST can improve data-driven medical research and provide a fast and accurate way to link individual information across several administrative databases. | en_US |
Affilliation | Universidade de São Paulo. Departamento de Análises Clínicas e Toxicológicas. São Paulo, SP, Brasil. | en_US |
Affilliation | Universidade de São Paulo. Departamento de Análises Clínicas e Toxicológicas. São Paulo, SP, Brasil. | en_US |
Affilliation | Universidade de São Paulo. Departamento de Análises Clínicas e Toxicológicas. São Paulo, SP, Brasil / Plataforma Científica Pasteur USP. São Paulo, SP, Brasil. | en_US |
Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil / Instituto Todos pela Saúde. São Paulo, SP, Brasil. | en_US |
Affilliation | Fundação de Vigilância em Saúde do Amazonas. Manaus, AM, Brasil. | en_US |
Affilliation | Universidade de São Paulo. Departamento de Microbiologia. São Paulo, SP, Brasil. | en_US |
Affilliation | Universidade de São Paulo. Departamento de Análises Clínicas e Toxicológicas. São Paulo, SP, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Universidade de São Paulo. Departamento de Análises Clínicas e Toxicológicas. São Paulo, SP, Brasil / Plataforma Científica Pasteur USP. São Paulo, SP, Brasil / Instituto Todos pela Saúde. São Paulo, SP, Brasil / Hospital Israelita Albert Einstein. São Paulo, SP, Brasil. | en_US |
Subject | NA-encoded | en_US |
Subject | Record linkage | en_US |
Subject | Genomic tools | en_US |
Subject | Epidemiology | en_US |
Subject | Blast | en_US |
DeCS | Epidemiology | en_US |