Author | Costa, José Fernando Oliveira | |
Author | Meira, Cássio Santana | |
Author | Neves, Maria Vitória Gomes das | |
Author | Reis, Bruna Padilha Zurita Claro Dos | |
Author | Soares, Milena Botelho Pereira | |
Access date | 2022-09-23T19:51:57Z | |
Available date | 2022-09-23T19:51:57Z | |
Document date | 2022 | |
Citation | COSTA, José Fernando Oliveira et al. Anti-inflammatory activities of betulinic acid: a review. Front. Pharmacol. V.13, p. 9, 2022. | en_US |
ISSN | 1663-9812 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/54867 | |
Sponsorship | PRONEX | en_US |
Language | por | en_US |
Publisher | Frontiers Media | en_US |
Rights | open access | en_US |
MeSH | Inflammation | en_US |
Subject in Portuguese | Ácido betulínico | en_US |
Subject in Portuguese | Terpenóides | en_US |
Subject in Portuguese | Imunomodulação | en_US |
Subject in Portuguese | Inflamação | en_US |
Title | Anti-inflammatory activities of betulinic acid: a review | en_US |
Type | Article | en_US |
DOI | 10.3389/fphar.2022.883857 | |
Abstract | Inflammatory diseases have a high prevalence and has become of great interest due to the increase in life expectancy and the costs to the health care system worldwide. Chronic diseases require long-term treatment frequently using corticosteroids and non-steroidal anti-inflammatory drugs, which are associated with diverse side effects and risk of toxicity. Betulinic acid, a lupane-type pentacyclic triterpene, is a potential lead compound for the development of new anti-inflammatory treatments, and a large number of derivatives have been produced and tested. The potential of betulinic acid and its derivatives has been shown in a number of pre-clinical studies using different experimental models. Moreover, several molecular mechanisms of action have also been described. Here we reviewed the potential use of betulinic acid as a promissory lead compound with anti-inflammatory activity and the perspectives for its use in the treatment of inflammatory conditions. | en_US |
Affilliation | Secretaria de Estado da Saúde da Bahia. Centro de Infusões e Medicamentos Especializados da Bahia. Salvador, BA, Brasil. | en_US |
Affilliation | Centro Universitário SENAI/CIMATEC. Instituto SENAI de Inovação em Sistemas Avançados de Saúde. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Centro Universitário SENAI/CIMATEC. Instituto SENAI de Inovação em Sistemas Avançados de Saúde. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Subject | Betulinic acid | en_US |
Subject | Terpenoids | en_US |
Subject | Immunomodulation | en_US |
Subject | Inflammation | en_US |
DeCS | Imunomodulação | en_US |
DeCS | Inflamação | en_US |