| Author | Pyrrho, Alexandre S. | |
| Author | Lenzi, Henrique Leonel | |
| Author | Ramos, Juliene Antonio | |
| Author | Moura Neto, Roberto | |
| Author | Cachem, Fabio Christiane O. F. | |
| Author | Silva, Célia Santos da | |
| Author | Takiya, Christina Maeda | |
| Author | Gattass, Cerli Rocha | |
| Access date | 2012-09-06T14:04:30Z | |
| Available date | 2012-09-06T14:04:30Z | |
| Document date | 2004 | |
| Citation | PYRRHO, A. S. ; LENZI, H. L. ; RAMOS, J. A. et al. Dexamethasone treatment improves morphological and hematological parameters in chronic experimental schitosomiasis. Parasitology Research, v. 92, n. 6, p. 478-483, 2004. | pt_BR |
| ISSN | 0932-0113 | |
| URI | https://www.arca.fiocruz.br/handle/icict/5486 | |
| Sponsorship | Acknowledgements This work was supported by FAPERJ, CNPq, FUJB, and FIOCRUZ. The authors are grateful to Dr. L. Correa for the Schistosoma mansoni cercariae. All experimental procedures were conducted in accordance with the Guidelines for Care and
Use of Laboratory Animals (CAUAP) of the Institute of Biophysics Carlos Chagas Filho, which conform to the National Institute of Health (Bethesda, MD, USA) guidelines. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Sprmger Verlag (Germany) | en |
| Rights | open access | |
| Title | Dexamethasone treatment improves morphological and hematological parameters in chronic experimental schistosomiasis | pt_BR |
| Type | Article | |
| DOI | DOI 10.1007/s00436-004-1078-8 | |
| Abstract | Schistosomiasis, a chronic disease with considerable social impact, is an important health problem in many countries. To investigate the possible use of immunomodulators as coadjuvants in the treatment of chronic Schistosoma mansoni infection, we evaluated the effect of dexamethasone on histological, hematological, and biochemical parameters that reflect disease severity and morbidity. Animals treated from the first day or after 35 days of infection, were analyzed. In both groups, dexamethasone: (1) induced a decrease in the number of granulomas in hepatic tissue without affecting the alanine aminotransferase profile, (2) reduced splenomegaly and hepatomegaly associated with disease, and (3) improved hemoglobin concentration, hematocrit values and reduced the percentage of reticulocytes, preventing the development of anemia that occurs in the chronic phase of infection. These data suggest that treatment with dexamethasone results in a mild course of murine schistosomiasis and point to this drug as a promising agent to complement S. mansoni specific treatment. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Departamento de Histologia e Embriologia. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil | pt_BR |
| Subject | Anti-Inflammatory Agents | pt_BR |
| Subject | Schistosomiasis mansoni | pt_BR |
| Subject | Dexamethasone | pt_BR |
| Subject | Hemoglobins | pt_BR |
| DeCS | Alanina Transaminase | pt_BR |
| DeCS | Antiinflamatórios | pt_BR |
| DeCS | Dexametasona | pt_BR |
| DeCS | Esquistossomose mansoni | pt_BR |
| DeCS | Hemoglobinas | pt_BR |
