| Author | Lima, Rosangela G | |
| Author | Van Weyenbergh, Johan Jozef Rosa Maria | |
| Author | Saraiva, Elvira Maria B | |
| Author | Barral Netto, Manoel | |
| Author | Castro Filho, Bernardo Galvão | |
| Author | Bou-Habib, Dumith Chequer | |
| Access date | 2012-09-06T17:39:06Z | |
| Available date | 2012-09-06T17:39:06Z | |
| Document date | 2002 | |
| Citation | LIMA, R.G. et al. The replication of human immunodeficiency virus type 1 in macrophages is enhanced after phagocytosis of apoptotic cells. Journal of Infectious Disease, v. 185, n. 11), p. 1561-6, Jun. 2002. | pt_BR |
| ISSN | 0022-1899 | |
| URI | https://www.arca.fiocruz.br/handle/icict/5488 | |
| Language | eng | pt_BR |
| Rights | open access | |
| Title | The replication of human immunodeficiency virus type 1 in macrophages is enhanced after phagocytosis of apoptotic cells. | pt_BR |
| Type | Article | pt_BR |
| Abstract | Clearance of apoptotic cells increases macrophage secretion of antiinflammatory mediators
and might modulate viral replication in human immunodeficiency virus (HIV) type 1–infected
macrophages. To study this, primary macrophages were infected with HIV-1 and exposed to
apoptotic cells. It was found that phagocytosis of apoptotic cells potently enhanced HIV-1
growth. The peptide Arg-Gly-Asp-Ser, which binds to integrin receptors, inhibited the uptake
of apoptotic cells and the subsequent enhancement of HIV-1 replication. Viral replication was
preceded by increased secretion of transforming growth factor (TGF)–b1 and partially reverted
by anti–TGF-b1 antibodies. Moreover, anti–TGF-b1 antibodies inhibited HIV-1 replication in
macrophages not exposed to apoptotic cells. A positive correlation was observed between TGFb1
production and HIV-1 growth, and the addition of TGF-b1 amplified HIV-1 replication in
macrophages from low TGF-b1 producers. The findings suggest that TGF-b1 favors HIV-1 replication
in macrophages and that the clearance of apoptotic cells by HIV-1–infected macrophages
contributes to persistent viremia in patients infected with HIV-1. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| DeCS | Apoptose | pt_BR |
| DeCS | HIV-1/fisiologia | pt_BR |
| DeCS | Macrófagos/virologia | pt_BR |
| DeCS | Fagocitose | pt_BR |
| DeCS | Replicação Viral | pt_BR |
| DeCS | Células Cultivadas | pt_BR |
| DeCS | Infecções por HIV/virologia | pt_BR |
| DeCS | HIV-1/patogenicidade | pt_BR |
| DeCS | Humanos | pt_BR |
| DeCS | Fator Transformador de Crescimento beta/imunologia | pt_BR |
| DeCS | Fator Transformador de Crescimento beta/metabolismo | pt_BR |
| DeCS | Fator Transformador de Crescimento beta1 | pt_BR |
