| Author | Rocha, Vinícius | |
| Author | Quadros, Helenita | |
| Author | Meira, Cássio | |
| Author | Silva, Laís | |
| Author | Carvalho, Dahara | |
| Author | Hodel, Katharine | |
| Author | Moreira, Diogo | |
| Author | Soares, Milena | |
| Access date | 2022-09-29T14:52:47Z | |
| Available date | 2022-09-29T14:52:47Z | |
| Document date | 2022 | |
| Citation | ROCHA, Vinícius et al. Potential of Triterpenic Natural Compound Betulinic Acid for Neglected Tropical Diseases New Treatments. Biomedicines, v. 10, n. 831, p. 1-16, 2022. | en_US |
| ISSN | 2227-9059 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/54933 | |
| Sponsorship | Fundação Oswaldo Cruz (Fiocruz) / Instituto Gonçalo Moniz (IGM).
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). | en_US |
| Language | eng | en_US |
| Publisher | MDPI | en_US |
| Rights | open access | en_US |
| MeSH | Leishmaniasis | en_US |
| MeSH | Chagas disease | en_US |
| MeSH | Malaria | en_US |
| MeSH | Neglected diseases | en_US |
| MeSH | Betulinic acid | en_US |
| MeSH | Therapeutics | en_US |
| Subject in Portuguese | Leishmaniose | en_US |
| Subject in Portuguese | Doença de Chagas | en_US |
| Subject in Portuguese | Malária | en_US |
| Subject in Portuguese | Doenças tropicais negligenciadas | en_US |
| Subject in Portuguese | Ácido betulínico | en_US |
| Subject in Portuguese | Tratamento | en_US |
| Title | Potential of triterpenic natural compound betulinic acid for neglected tropical diseases new treatments | en_US |
| Type | Article | en_US |
| DOI | 10.3390/biomedicines10040831 | |
| Abstract | Neglected tropical diseases are one of the most important public health problems in many countries around the world. Among them are leishmaniasis, Chagas disease, and malaria, which contribute to more than 250 million infections worldwide. There is no validated vaccine to prevent these infections and the treatments available are obsolete, highly toxic, and non-effective due to parasitic drug resistance. Additionally, there is a high incidence of these diseases, and they may require hospitalization, which is expensive to the public health systems. Therefore, there is an urgent need to develop new treatments to improve the management of infected people, control the spread of resistant strains, and reduce health costs. Betulinic acid (BA) is a triterpene natural product which has shown antiparasitic activity against Leishmania, Trypanosoma cruzi, and Plasmodium. Here, we review the main results regarding the in vitro and in vivo pharmacological activity of BA and its derivatives against these parasites. Some chemical modifications of BA have been shown to improve its activities against the parasites. Further improvement on studies of drug-derived, as well as structure–activity relationship, are necessary for the development of new betulinic acid-based treatments. | en_US |
| Affilliation | Instituto de Tecnologia em Saúde (SENAI / CIMATEC / ITS). Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
| Affilliation | Instituto de Tecnologia em Saúde (SENAI / CIMATEC / ITS). Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
| Affilliation | Instituto de Tecnologia em Saúde (SENAI / CIMATEC / ITS). Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
| Affilliation | Instituto de Tecnologia em Saúde (SENAI / CIMATEC / ITS). Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
| Subject | Leishmaniasis | en_US |
| Subject | Chagas disease | en_US |
| Subject | Malaria | en_US |
| Subject | Neglected tropical diseases | en_US |
| Subject | Betulinic acid | en_US |
| Subject | Treatment | en_US |
| DeCS | Leishmaniose | en_US |
| DeCS | Doença de chagas | en_US |
| DeCS | Malária | en_US |
| DeCS | Doenças negligenciadas | en_US |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
