| Author | Santos, Lucas David Rodrigues dos | |
| Author | Santos, Agatha Emanuelle Soares dos | |
| Author | Cerávolo, Isabela Penna | |
| Author | Figueiredo, Flávio Júnior Barbosa | |
| Author | Souza, Marcus Vinícius Dias | |
| Access date | 2022-10-04T18:42:14Z | |
| Available date | 2022-10-04T18:42:14Z | |
| Document date | 2018 | |
| Citation | SANTOS, Lucas David Rodrigues dos et al. Antibiofilm activity of black tea leaf extract, its cytotoxicity and interference on the activity of antimicrobial drugs. Biointerface Research in Applied Chemistry , v. 8, p. 3565-3569, 2018. | en_US |
| ISSN | 2069-5837 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/54989 | |
| Language | eng | en_US |
| Publisher | Universidade e Institutos de Pesquisa da Romania | en_US |
| Rights | restricted access | |
| Title | Antibiofilm activity of black tea leaf extract, its cytotoxicity and interference on the activity of antimicrobial drugs | en_US |
| Type | Article | |
| Abstract | Bacterial resistance to antimicrobial drugs is a pressing concern for public health, being biofilms critical contributors to this resistance phenomenon. In a context of lack of new antimicrobial drugs, natural products represent new possibilities for clinical treatments of infectious diseases. Black tea contains secondary metabolites that have been proved to be safe and beneficial for human health. However, some aspects of its antimicrobial potential remain unclear, including its antibiofilm activity. In this study, we provide evidence of the antimicrobial activity of black tea extract against clinical isolates of Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli, and for the first time, we describe the antibiofilm potential of this extract against these species. Cytotoxicity was not detected in our in vitro assays conducted using BGM cells. We conducted assays with the extract and antimicrobial drugs to simulate combination therapy strategies designed to prevent bacterial resistance, and synergism and antagonism results were observed. Our data open doors for more studies with isolated molecules of the extract towards the development of effective antimicrobial therapies supported by in vivo data | en_US |
| Affilliation | Faculdade Santo Agostinho. Sete Lagoas, MG, Brasil | en_US |
| Affilliation | Faculdade Santo Agostinho. Sete Lagoas, MG, Brasil | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brasil | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brasil/Universidade Vale do Rio Doce. | en_US |
| Affilliation | Universidade do Vale do Rio Doce. Faculade de Ciências da Saúde. Governador Valadares, MG, Brasil | en_US |
| Subject | Antimicrobial | en_US |
| Subject | Biofilm | en_US |
| Subject | Black tea | en_US |
| Subject | Cytotoxicity | en_US |
| Subject | Pseudomonas aeruginosa | en_US |
| Subject | Escherichia coli | en_US |
| Subject | Staphylococcus Aureus | en_US |
