| Author | Zhang, Zeli | |
| Author | Mateus, Jose | |
| Author | Coelho, Camila H. | |
| Author | Dan, Jennifer M. | |
| Author | Moderbacher, Carolyn Rydyznski | |
| Author | Gálvez, Rosa Isela | |
| Author | Cortes, Fernanda H. | |
| Author | Grifoni, Alba | |
| Author | Tarke, Alison | |
| Author | Chang, James | |
| Author | Escarrega, E. Alexandar | |
| Author | Kim, Christina | |
| Author | Goodwin, Benjamin | |
| Author | Bloom, Nathaniel I. | |
| Author | Frazier, April | |
| Author | Weiskopf, Daniela | |
| Author | Sette, Alessandro | |
| Author | Crotty, Shane | |
| Access date | 2022-10-06T20:13:30Z | |
| Available date | 2022-10-06T20:13:30Z | |
| Document date | 2022 | |
| Citation | ZHANG, Zeli et al. Humoral and cellular immune memory to four COVID-19 vaccines. Cell, p. 2434-2451, July 2022. | en_US |
| ISSN | 2073-4409 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/55038 | |
| Description | Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this
research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. | |
| Language | eng | en_US |
| Publisher | Elsevier | en_US |
| Rights | open access | |
| Title | Humoral and cellular immune memory to four COVID-19 vaccines | en_US |
| Type | Article | |
| DOI | 10.1016/j.cell.2022.05.022 | |
| Abstract | Multiple COVID-19 vaccines, representing diverse vaccine platforms, successfully protect against symptomatic
COVID-19 cases and deaths. Head-to-head comparisons of T cell, B cell, and antibody responses to
diverse vaccines in humans are likely to be informative for understanding protective immunity against
COVID-19, with particular interest in immune memory. Here, SARS-CoV-2-spike-specific immune responses
to Moderna mRNA-1273, Pfizer/BioNTech BNT162b2, Janssen Ad26.COV2.S, and Novavax NVX-CoV2373
were examined longitudinally for 6 months 100% of individuals made memory CD4+ T cells, with cTfh and
CD4-CTL highly represented after mRNA or NVX-CoV2373 vaccination. mRNA vaccines and Ad26.COV2.S
induced comparable CD8+ T cell frequencies, though only detectable in 60–67% of subjects at 6 months.
A differentiating feature of Ad26.COV2.S immunization was a high frequency of CXCR3+ memory B cells.
mRNA vaccinees had substantial declines in antibodies, while memory T and B cells were comparatively stable.
These results may also be relevant for insights against other pathogens. | en_US |
| Affilliation | Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA. | en_US |
| Affilliation | Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA. | en_US |
| Affilliation | Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA. | en_US |
| Affilliation | Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA / Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California. San Diego, CA, USA. | en_US |
| Affilliation | Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA. | en_US |
| Affilliation | Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA. | en_US |
| Affilliation | Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA. | en_US |
| Affilliation | Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA. | en_US |
| Affilliation | Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA. | en_US |
| Affilliation | Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA. | en_US |
| Affilliation | Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA. | en_US |
| Affilliation | Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA. | en_US |
| Affilliation | Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA. | en_US |
| Affilliation | Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA. | en_US |
| Affilliation | Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA. | en_US |
| Affilliation | Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA / Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego. San Diego, CA, USA. | en_US |
| Affilliation | Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA / Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California. San Diego, CA, USA. | en_US |
| Subject | COVID-19 | en_US |
| Subject | Vaccines | en_US |
| Subject | Immune memory | en_US |
| Subject | Humoral e celular | en_US |
| Subject | COVID-19 | en_US |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
