| Author | Erton, Zeynep Belce | |
| Author | Sevim, Ecem | |
| Author | Jesús, Guilherme Ramires de | |
| Author | Cervera, Ricard | |
| Author | Lanlan, Ji | |
| Author | Pengo, Vittorio | |
| Author | Ugarte, Amaia | |
| Author | Andrade, Danieli | |
| Author | Andreoli, Laura | |
| Author | Tatsuya, Atsumi | |
| Author | Fortin, Paul R. | |
| Author | Gerosa, Maria | |
| Author | Yu, Zuo | |
| Author | Petri, Michelle | |
| Author | Sciascia, Savino | |
| Author | Tektonidou, Maria G. | |
| Author | Aguirre-Zamorano, Maria Angeles | |
| Author | Branch, D. Ware | |
| Author | Erkan, Doruk | |
| Access date | 2022-10-10T14:05:53Z | |
| Available date | 2022-10-10T14:05:53Z | |
| Document date | 2022 | |
| Citation | ERTON, Zeynep Belce et al. Pregnancy outcomes in antiphospholipid antibody positive patients: prospective results from the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) Clinical Database and Repository ('Registry'). Lupus Science & Medicine, v. 9, n. e000633, p. 1-10, 14 June 2022. | en_US |
| ISSN | 2053-8790 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/55069 | |
| Language | eng | en_US |
| Publisher | BMJ Publishing Group | en_US |
| Rights | open access | |
| Title | Pregnancy outcomes in antiphospholipid antibody positive patients: prospective results from the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) Clinical Database and Repository ('Registry') | en_US |
| Type | Article | en_US |
| DOI | 10.1136/lupus-2021-000633 | |
| Abstract | Objectives: To describe the outcomes of pregnancies in antiphospholipid antibody (aPL)-positive patients since the inception of the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking Registry. Methods: We identified persistently aPL-positive patients recorded as ‘pregnant’ during prospective follow-up, and defined ‘aPL-related outcome’ as a composite of: (1) Preterm live delivery (PTLD) at or before 37th week due to pre-eclampsia (PEC), eclampsia, small-for-gestational age (SGA) and/or placental insufficiency (PI); or (2) Otherwise unexplained fetal death after the 10th week of gestation. The primary objective was to describe the characteristics of patients with and without aPL-related composite outcomes based on their first observed pregnancies following registry recruitment. Results: Of the 55 first pregnancies observed after registry recruitment among nulliparous and multiparous participants, 15 (27%) resulted in early pregnancy loss <10 weeks gestation. Of the remaining 40 pregnancies: (1) 26 (65%) resulted in term live delivery (TLD), 4 (10%) in PTLD between 34.0 weeks and 36.6 weeks, 5 (12.5%) in PTLD before 34th week, and 5 (12.5%) in fetal death (two associated with genetic anomalies); and (2) The aPL-related composite outcome occurred in 9 (23%). One of 26 (4%) pregnancies with TLD, 3/4 (75%) with PTLD between 34.0 weeks and 36.6 weeks, and 3/5 (60%) with PTLD before 34th week were complicated with PEC, SGA and/or PI. Fifty of 55 (91%) pregnancies were in lupus anticoagulant positive subjects, as well as all pregnancies with aPL-related composite outcome. Conclusion: In our multicentre, international, aPL-positive cohort, of 55 first pregnancies observed prospectively, 15 (27%) were complicated by early pregnancy loss. Of the remaining 40 pregnancies, composite pregnancy morbidity was observed in 9 (23%) pregnancies. | en_US |
| Affilliation | Hospital for Special Surgery. Divison of Rheumatology. New York, NY, USA | en_US |
| Affilliation | Yeshiva University. Albert Einstein College of Medicine. Bronx, NY, USA / Montefiore Medical Center. Internal Medicine. Bronx, NY, USA. | en_US |
| Affilliation | Universidade do Estado do Rio de Janeiro. Centro Biomédico. Faculdade de Ciências Médicas. Departamento de Ginecologia e Obstetrícia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Institut Clínic de Medicina i Dermatologia. Hospital Clínic de Barcelona. Autoimmune Diseases. Barcelona, Spain. | en_US |
| Affilliation | Peking University First Hospital. Department of Rheumatology and Clinical Immunology. Beijing, Beijing, China. | en_US |
| Affilliation | University of Padova. Cardiac Thoracic and Vascular Sciences. Padua, Italy. | en_US |
| Affilliation | Hospital de Cruces. Internal Medicine. Barkaldo, Spain. | en_US |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina. São Paulo, SP, Brasil. | en_US |
| Affilliation | University of Brescia. Department of Clinical and Experimental Sciences. Brescia, Italy / ASST Spedali Civili di Brescia. Unit of Rheumatology and Clinical Immunology. Brescia, Italy. | en_US |
| Affilliation | Hokkaido University. School of Medicine. Medicine II. Sapporo, Japan. | en_US |
| Affilliation | Centre Hospitalier de l’Université Laval. Medicine - Rheumatology. Quebec City, Quebec, Canada. | en_US |
| Affilliation | University of Milano. Division of Rheumatology. Dept. of Clinical & Community Science. Milano, Italy. | en_US |
| Affilliation | University of Michigan. Internal Medicine/Division of Rheumatology. Ann Arbor, Michigan, USA. | en_US |
| Affilliation | Johns Hopkins University. Rheumatology. Baltimore, Maryland, USA. | en_US |
| Affilliation | Università di Torino. Ospedale Torino Nord Emergenza San G. Bosco. Struttura Complessa a Direzione Universitaria di Immunologia Clinica. Centro di Ricerche di Immunopatologia e Documentazione su Malattie Rare. Dipartimento di Malattie Rare, Immunologiche, Ematologiche ed Immunoematologiche. Torino, Italy. | en_US |
| Affilliation | National and Kapodistrian University of Athens. First Department of Propaedeutic Internal Medicine. Athens, Greece. | en_US |
| Affilliation | University Hospital “Reina Sofia”. Rheumatology. Cordoba, Spain. | en_US |
| Affilliation | University of Utah. Health Sciences Center. Maternal-Fetal Medicine. Salt Lake City, Utah, USA / Intermountain Healthcare. Maternal-Fetal Medicine. Salt Lake City, Utah, USA. | en_US |
| Affilliation | Weill Cornell Medicine. Hospital for Special Surgery. Barbara Volcker Center for Women and Rheumatic Diseases. Rheumatology. New York, NY, USA. | en_US |
| Subject | AntiPhospholipid Syndrome | en_US |
| Subject | APS ACTION | en_US |
| Subject | Fetal death | en_US |
| Subject | Pregnancy loss | en_US |
| Subject | Demographics features | en_US |
| Subject | Clinical features | en_US |
| e-ISSN | 2053-8790 | |
