| Author | Moreira, Cristina K. | |
| Author | Rodrigues, Flávia Guimaraes | |
| Author | Ghosh, Anil | |
| Author | Varotti, Fernando de Pilla | |
| Author | Miranda, Antonio | |
| Author | Daffre, Sirlei | |
| Author | Jacobs-Lorena, Marcelo | |
| Author | Moreira, Luciano Andrade | |
| Access date | 2022-10-11T17:12:25Z | |
| Available date | 2022-10-11T17:12:25Z | |
| Document date | 2007 | |
| Citation | MOREIRA, Cristina K. et al. Effect of the antimicrobial peptide gomesin against different life stages of Plasmodium spp. Experimental Parasitology, V 116, N. 4, p. 346-353, 2007. Doi: 10.1016/j.exppara.2007.01.022 | en_US |
| ISSN | 0014-4894 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/55110 | |
| Language | eng | en_US |
| Publisher | Elsevier Inc | en_US |
| Rights | restricted access | |
| Title | Effect of the antimicrobial peptide gomesin against different life stages of Plasmodium spp | en_US |
| Type | Article | |
| DOI | 10.1016/j.exppara.2007.01.022 | |
| Abstract | While seeking strategies for interfering with Plasmodium development in vertebrate/invertebrate hosts, we tested the activity of gomesin, an antimicrobial peptide isolated from the hemocytes of the spider Acanthoscurria gomesiana. Gomesin was tested against asexual, sexual and pre-sporogonic forms of Plasmodium falciparum and Plasmodium berghei parasites. The peptide inhibited the in vitro growth of intraerythrocytic forms of P. falciparum.When gomesin was added to in vitro culture of P. berghei mature gametocytes, it significantly inhibited the exflagellation of male gametes and the formation of ookinetes. In vivo, the peptide reduced the number of oocysts of both Plasmodium species in Anopheles stephensi mosquitoes, and did not appear to affect the mosquitoes. These properties make gomesin an excellent candidate as a transmission blocking agent for the genetic engineering of mosquitoes. | en_US |
| Affilliation | Department of Molecular Microbiology and Immunology. John Hopkins Bloomberg School of Public Health. Malaria Research Institute. Baltimore, MD, USA | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Malária. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Department of Molecular Microbiology and Immunology. John Hopkins Bloomberg School of Public Health. Malaria Research Institute. Baltimore, MD, USA | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Malária. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Universidade Federal de São Paulo. Departamento de Biofísica. São Paulo, SP, Brazil | en_US |
| Affilliation | Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brazil | en_US |
| Affilliation | Department of Molecular Microbiology and Immunology. John Hopkins Bloomberg School of Public Health. Malaria Research Institute. Baltimore, MD, USA | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Malária. Belo Horizonte, MG, Brazil | en_US |
| Subject | antimicrobial peptide | en_US |
| Subject | gomesin | en_US |
| Subject | malaria | en_US |
| Subject | mosquito | en_US |
| Subject | ookinete | en_US |
| Subject | oocyst | en_US |
| Subject | exflagellation | en_US |
