| Author | Tanaka, Tayana Serpa Ortiz | |
| Author | Cesar, Gabriela Alves | |
| Author | Rezende, Grazielli Rocha de | |
| Author | Puga, Marco Antonio Moreira | |
| Author | Weis-Torres, Sabrina Moreira dos Santos | |
| Author | Bandeira, Larissa Melo | |
| Author | Pompílio, Maurício Antônio | |
| Author | Croda, Julio | |
| Author | Guimarães, Monick Lindenmeyer Guimarães | |
| Author | Castro, Ana Rita Coimbra Motta | |
| Access date | 2022-10-12T12:13:59Z | |
| Available date | 2022-10-12T12:13:59Z | |
| Document date | 2022 | |
| Citation | TANAKA, Tayana Serpa Ortiz et al. Molecular Epidemiology of HIV-1 among Prisoners in Central Brazil and Evidence of Transmission Clusters. Viruses, v. 14, 1660, p. 1 - 15, July 2022. | en_US |
| ISSN | 1999-4915 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/55118 | |
| Language | eng | en_US |
| Publisher | MDPI | en_US |
| Rights | open access | |
| Subject in Portuguese | HIV | en_US |
| Subject in Portuguese | População vulnerável | en_US |
| Subject in Portuguese | Epidemiologia molecular | en_US |
| Subject in Portuguese | Mutações de resistência a medicamentos | en_US |
| Subject in Portuguese | Rede de transmissão | en_US |
| Title | Molecular Epidemiology of HIV-1 among Prisoners in Central Brazil and Evidence of Transmission Clusters | en_US |
| Type | Article | |
| DOI | 10.3390/v14081660 | |
| Abstract | Higher rates of human immunodeficiency virus (HIV) infection have been detected in
prisoners when compared with the general population, but research into HIV molecular epidemiology
and its transmission network has been lacking among them. Thus, this study aimed to verify potential
HIV molecular transmission networks among prisoners. In addition, we aimed to describe the
mutations related to antiretroviral resistance in these isolates. Thus, we conducted a cross-sectional
survey from 2013 to 2018 in prisons in Central-Western Brazil, and the final sampling composed of
84 prisoners. Proviral DNA was extracted from each whole blood sample followed by amplification
of the partial polymerase gene and sequencing. Forty-nine sequences (58.3%) were classified as
subtype B, followed by C (14.3%), D, and F1 (2.4% each). A complex and dynamic HIV-1 epidemic
is observed in the prisons, as 25% of the sequences were recombinant forms. We detected 15 HIV
transmission clusters composed of at least two sequences, that included not only prisoners but also
individuals from the general population from the same State with a variety of risk behaviors. Thirtytwo
percent (32.0%) of treatment-experienced prisoners had at least one drug resistance mutation
(DRM), while transmitted DRMs were found in 5.9% of the prisoners. We highlight the urgent need
for routine surveillance of HIV-1 infection including resistance genotypic tests considering the high
disease burden, risky behaviors inside prisons, and the dynamic relationship of prisoners with the
outside community. | en_US |
| Affilliation | Universidade Federal do Mato Grosso do Sul. Laboratório de Imunologia Clínica. Campo Grande, MS, Brasil. | en_US |
| Affilliation | Universidade Federal do Mato Grosso do Sul. Laboratório de Imunologia Clínica. Campo Grande, MS, Brasil. | en_US |
| Affilliation | Universidade Federal do Mato Grosso do Sul. Laboratório de Imunologia Clínica. Campo Grande, MS, Brasil. | en_US |
| Affilliation | Universidade Federal do Mato Grosso do Sul. Laboratório de Imunologia Clínica. Campo Grande, MS, Brasil. | en_US |
| Affilliation | Universidade Federal do Mato Grosso do Sul. Laboratório de Imunologia Clínica. Campo Grande, MS, Brasil. | en_US |
| Affilliation | Universidade Federal do Mato Grosso do Sul. Laboratório de Imunologia Clínica. Campo Grande, MS, Brasil. | en_US |
| Affilliation | Universidade Federal do Mato Grosso do Sul. Laboratório de Imunologia Clínica. Campo Grande, MS, Brasil. | en_US |
| Affilliation | Universidade Federal do Mato Grosso do Sul. Laboratório de Imunologia Clínica. Campo Grande, MS, Brasil / Fundação Oswaldo Cruz. Fiocruz Mato Grosso do Sul. Campo Grande, MS, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Universidade Federal do Mato Grosso do Sul. Laboratório de Imunologia Clínica. Campo Grande, MS, Brasil / Fundação Oswaldo Cruz. Fiocruz Mato Grosso do Sul. Campo Grande, MS, Brasil. | en_US |
| Subject | HIV | en_US |
| Subject | Vulnerable population | en_US |
| Subject | Drug resistance mutations | en_US |
| Subject | Transmission network | en_US |
| Subject | Molecular epidedmiology | en_US |
| xmlui.metadata.dc.subject.ods | 01 Erradicação da pobreza | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
| xmlui.metadata.dc.subject.ods | 10 Redução das desigualdades | |
