| Author | Duarte, Geraldo | |
| Author | Muresan, Petronella | |
| Author | Ward, Shawn | |
| Author | Laimon, Lauren | |
| Author | Pelton, Stephen I. | |
| Author | Canniff, Jennifer | |
| Author | Golner, Amanda Golner | |
| Author | Bone, Frederic | |
| Author | Newton, Lassallete | |
| Author | Fenton, Terence | |
| Author | Coutinho, Conrado M. | |
| Author | João, Esau C. | |
| Author | Santos, Breno R. | |
| Author | Pilotto, Jose Henrique da Silva | |
| Author | Oliveira, Ricardo H. | |
| Author | Pinto, Jorge A. | |
| Author | Machado, Elizabeth S. | |
| Author | Kreitchman, Regis | |
| Author | Chakhtoura, Nahida | |
| Author | Mussi-Pinhata, Marisa M. | |
| Author | Weinberg, Adriana | |
| Author | for NICHD P1091 Study Team | |
| Access date | 2022-11-08T19:13:50Z | |
| Available date | 2022-11-08T19:13:50Z | |
| Document date | 2021 | |
| Citation | DUARTE, Geraldo et al. Immunogenicity of Conjugated and Polysaccharide Pneumococcal Vaccines Administered During Pregnancy or Postpartum to Women With HIV. The Journal of Infectious Diseases, v. 225, p. 1021–1031, 2022. | en_US |
| ISSN | 1413-8670 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/55540 | |
| Language | eng | en_US |
| Publisher | Oxford University Press | en_US |
| Rights | open access | |
| Subject in Portuguese | Arte | en_US |
| Subject in Portuguese | Infecção pelo HIV | en_US |
| Subject in Portuguese | PCV | en_US |
| Subject in Portuguese | PPV | en_US |
| Subject in Portuguese | Gravidez | en_US |
| Title | Immunogenicity of Conjugated and Polysaccharide Pneumococcal Vaccines Administered During Pregnancy or Postpartum to Women With HIV | en_US |
| Type | Article | |
| DOI | 10.1093/infdis/jiab567 | |
| Abstract | Background. Pneumococcal vaccination is recommended in people with HIV, prioritizing PCV. We compared the immunogenicity
of PCV-10 and PPV-23 administered antepartum or postpartum.
Methods. This double-blind study randomized 346 pregnant women with HIV on antiretrovirals to PCV-10, PPV-23, or placebo
at 14–34 weeks gestational age. Women who received placebo antepartum were randomized at 24 weeks postpartum to PCV-10 or
PPV-23. Antibodies against 7 serotypes common to both vaccines and 1 serotype only in PPV-23 were measured by ELISA/chemiluminescence;
B- and T-cell responses to serotype 1 by FLUOROSPOT; and plasma cytokines/chemokines by chemiluminescence.
Results. Antibody responses were higher after postpartum versus antepartum vaccination. PCV-10 generated lower antibody
levels than PPV-23 against 4 and higher against 1 of 7 common serotypes. Additional factors associated with high postvaccination
antibody concentrations were high prevaccination antibody concentrations and CD4+ cells; low CD8+ cells and plasma HIV RNA;
and several plasma cytokines/chemokines. Serotype 1 B- and T-cell memory did not increase after vaccination.
Conclusions. Antepartum immunization generated suboptimal antibody responses, suggesting that postpartum booster doses
may be beneficial and warrant further studies. Considering that PCV-10 and PPV-23 had similar immunogenicity, but PPV-23 covered
more serotypes, use of PPV-23 may be prioritized in women with HIV on antiretroviral therapy. | en_US |
| Affilliation | Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Ginecologia e Obstetrícia. Ribeirão Preto, SP, Brasil. | en_US |
| Affilliation | Frontier Science Foundation. Brookline, Massachusetts, USA. | en_US |
| Affilliation | Frontier Science Foundation. Brookline, Massachusetts, USA. | en_US |
| Affilliation | Westat, Rockville. Maryland, USA. | en_US |
| Affilliation | Boston University School of Medicine. Boston, Massachusetts, USA. | en_US |
| Affilliation | Department of Pediatrics, University of Colorado Anschutz Medical Campus. Aurora, Colorado, USA. | en_US |
| Affilliation | Frontier Science Foundation. Buffalo, New York, USA. | en_US |
| Affilliation | Frontier Science Foundation. Buffalo, New York, USA. | en_US |
| Affilliation | Westat, Rockville. Maryland, USA. | en_US |
| Affilliation | Frontier Science Foundation. Brookline, Massachusetts, USA. | en_US |
| Affilliation | Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Ginecologia e Obstetrícia. Ribeirão Preto, SP, Brasil. | en_US |
| Affilliation | Hospital dos Servidores do Estado. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Hospital Nossa Senhora da Conceicao. Porto Alegre, RS, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil / Hospital Geral de Nova Iguaçu. Nova Iguaçu, RJ, Brasil. | en_US |
| Affilliation | Instituto de Puericultura e Pediatra Matagão Gesteira. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Escola de Medicina. Belo Horizonte, MG, Brasil. | en_US |
| Affilliation | Instituto de Puericultura e Pediatra Matagão Gesteira. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Universidade Federal de Ciências da Saúde de Porto Alegre. Porto Alegre, RS, Brasil. | en_US |
| Affilliation | Eunice Kennedy Shriver National Institute of Child Health and Human Development. Bethesda, Maryland, USA. | en_US |
| Affilliation | Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Pediatria. Ribeirão Preto, SP, Brasil. | en_US |
| Affilliation | Department of Pediatrics, University of Colorado Anschutz Medical Campus. Aurora, Colorado, USA. | en_US |
| Affilliation | for NICHD P1091 Study Team | en_US |
| Subject | ART | en_US |
| Subject | HIV infection | en_US |
| Subject | PCV | en_US |
| Subject | PPV | en_US |
| Subject | Pregnancy | en_US |
