| Author | Villalva-Serra, Klauss | |
| Author | Barreto-Duarte, Beatriz | |
| Author | Nunes, Vanessa M. | |
| Author | Menezes, Rodrigo C. | |
| Author | Rodrigues, Moreno M. S. | |
| Author | Queiroz, Artur T. L. | |
| Author | Arriaga, María B. | |
| Author | Cordeiro-Santos, Marcelo | |
| Author | Kritski, Afrânio L. | |
| Author | Sterling, Timothy R. | |
| Author | Araújo-Pereira, Mariana | |
| Author | Andrade, Bruno B. | |
| Access date | 2022-11-11T18:35:22Z | |
| Available date | 2022-11-11T18:35:22Z | |
| Document date | 2022 | |
| Citation | VILLALVA-SERRA, Klauss et al. Tuberculosis treatment outcomes of diabetic and non-diabetic TB/HIV co-infected patients: A nationwide observational study in Brazil. Frontiers in Medicine, v. 9, p. 1-12, 2022. | en_US |
| ISSN | 2296-858X | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/55604 | |
| Language | eng | en_US |
| Publisher | Frontiers Media | en_US |
| Rights | open access | en_US |
| Title | Tuberculosis treatment outcomes of diabetic and non-diabetic TB/HIV co-infected patients: A nationwide observational study in Brazil | en_US |
| Type | Article | en_US |
| DOI | 10.3389/fmed.2022.972145 | |
| Abstract | Background: Tuberculosis (TB) is a worldwide public health problem, especially in countries that also report high numbers of people living with HIV (PLWH) and/or diabetes mellitus (DM). However, the unique features of persons with TB-HIV-DM are incompletely understood. This study compared anti-TB treatment (ATT) outcomes of diabetic and non-diabetic TB/HIV co-infected patients.
Methods: A nationwide retrospective observational investigation was performed with data from the Brazilian Tuberculosis Database System among patients reported to have TB-HIV co-infection between 2014 and 2019. This database includes all reported TB cases in Brazil. Exploratory and association analyses compared TB treatment outcomes in DM and non-DM patients. Unfavorable outcomes were defined as death, treatment failure, loss to follow-up or recurrence. Multivariable stepwise logistic regressions were used to identify the variables associated with unfavorable ATT outcomes in the TB-HIV population.
Results: Of the 31,070 TB-HIV patients analyzed, 999 (3.2%) reported having DM. However, in these TB-HIV patients, DM was not associated with any unfavorable treatment outcome [adjusted Odds Ratio (aOR): 0.97, 95% CI: 0.83-1.12, p = 0.781]. Furthermore, DM was also not associated with any specific type of unfavorable outcome in this study. In both the TB-HIV group and the TB-HIV-DM subpopulation, use of alcohol, illicit drugs and tobacco, as well as non-white ethnicity and prior TB were all characteristics more frequently observed in persons who experienced an unfavorable ATT outcome.
Conclusion: DM is not associated with unfavorable TB treatment outcomes in persons with TB-HIV, including death, treatment failure, recurrence and loss to follow up. However, consumption habits, non-white ethnicity and prior TB are all more frequently detected in those with unfavorable outcomes in both TB-HIV and TB-HIV-DM patients. | en_US |
| Affilliation | Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Universidade Salvador. Curso de Medicina. Salvador, BA, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brazil / Universidade Federal do Rio de Janeiro. Programa de Pós-Graduação em Clínica Médica. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Universidade Salvador. Curso de Medicina. Salvador, BA, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil /Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brazil / Grupo de Estudos em Medicina Intensiva. Salvador, BA, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Laboratório de Análise e Visualização de Dados. Porto Velho, RO, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Universidad Peruana Cayetano Heredia. Instituto de Medicina Tropical Alexander Von Humboldt. Lima, Peru. | en_US |
| Affilliation | Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brazil / Fundação Medicina Tropical Doutor Heitor Vieira Dourado. Manaus, AM, Brazil / Universidade Nilton Lins. Faculdade de Medicina. Manaus, AM, Brazil. | en_US |
| Affilliation | Universidade Federal do Rio de Janeiro. Programa de Pós-Graduação em Clínica Médica. Rio de Janeiro, RJ, Brazil / Universidade Federal do Rio de Janeiro. Programa Acadêmico de Tuberculose da Faculdade de Medicina. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Vanderbilt University School of Medicine. Department of Medicine. Division of Infectious Diseases. Nashville, TN, United States. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil /Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brazil / Faculdade de Ciência e Tecnologia. Curso de Medicina. Salvador, BA, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil /Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brazil / Faculdade de Ciência e Tecnologia. Curso de Medicina. Salvador, BA, Brazil / Universidade Salvador. Curso de Medicina. Salvador, BA, Brazil / Vanderbilt University School of Medicine. Department of Medicine. Division of Infectious Diseases. Nashville, TN, United States. | en_US |
| Subject | Antiretroviral therapy (ART) | en_US |
| Subject | HIV | en_US |
| Subject | Diabetes | en_US |
| Subject | Treatment outcome | en_US |
| Subject | Tuberculosis | en_US |
